M5280

Mastoparan, Vespula lewisii

≥97% (HPLC), powder

• Formule empirique (notation de Hill) : C₇₀H₁₃₁N₁₉O₁₅
• Numéro CAS: 72093-21-1
• Poids moléculaire : 1478.91
• Beilstein: 5491949
• Numéro MDL: MFCD00076865
• Code UNSPSC : 41106300
• ID de substance PubChem : 329818006
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Essai: ≥97% (HPLC)
• Forme: powder
• Couleur: white
• Température de stockage: −20°C
• Chaîne SMILES: CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NC([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O
• InChI: 1S/C70H131N19O15/c1-17-40(11)55(75)69(103)88-53(35-54(74)90)68(102)87-52(34-39(9)10)67(101)83-46(25-19-22-28-71)62(96)78-45(16)61(95)86-50(32-37(5)6)65(99)79-42(13)58(92)77-43(14)60(94)85-51(33-38(7)8)66(100)80-44(15)59(93)81-47(26-20-23-29-72)63(97)82-48(27-21-24-30-73)64(98)89-56(41(12)18-2)70(104)84-49(57(76)91)31-36(3)4/h36-53,55-56H,17-35,71-73,75H2,1-16H3,(H2,74,90)(H2,76,91)(H,77,92)(H,78,96)(H,79,99)(H,80,100)(H,81,93)(H,82,97)(H,83,101)(H,84,104)(H,85,94)(H,86,95)(H,87,102)(H,88,103)(H,89,98)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,55-,56-/m0/s1
• Clé InChI: MASXKPLGZRMBJF-MVSGICTGSA-N
• Informations sur le gène: human ... CALM1(801) , PLA2R1(22925) ; mouse ... CALM1(12313) , PLA2R1(18779) ; rat ... CALM1(24242) , PLA2R1(295631)

Description

Amino Acid Sequence

Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2

Description générale

Mastoparan is a cationic, amphiphilic, tetradecapeptide amide. It is composed of the restricted amino acid and the repeated sequence.[1] This protein is a nonspecific secretagogue isolated from venom of wasp.[2]

Application

Mastoparan has been used as a calmodulin antagonist.[3]

Actions biochimiques/physiologiques

Mast cell degranulating peptide. Activates phospholipase A₂; inhibits calmodulin. Cell permeable; stimulates exocytosis and phosphoinositide breakdown.

Mastoparan effectively stimulates exocytosis from diverse mammalian cells. The encoded protein facilitates the secretion of histamine from mast cells, serotonin from platelets, catecholamines from chromaffin cells and prolactin from the anterior pituitary.[2] In addition, it is also involved in activation of Phospholipase A2 and phosphoinositides (Pl) break down. Mastoparan functions as an inhibitor for calmodulin-stimulated phosphodiesterase.[4][5][6] Mastoparan helps in mitochondrial permeability transition by enhancing an apparent bimodal mechanism of action.[7]

Autres remarques

Lyophilized from 0.1% TFA in H2O

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)