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Merck
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I2785

Sigma-Aldrich

IRAK4, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyme(s) :

IPD1, NY-REN-64, REN64

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About This Item

Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32

Produit recombinant

expressed in baculovirus infected Sf9 cells

Niveau de qualité

200

Gamme de produits

PRECISIO® Kinase

Pureté

≥70% (SDS-PAGE)

Forme

buffered aqueous glycerol solution

Activité spécifique

378-512 nmol/min·mg

Poids mol.

~81 kDa

Numéro d'accès UniProt

Q9NWZ3

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... IRAK4(51135)

Actions biochimiques/physiologiques

IRAK4 (interleukin-1 receptor-associated kinase 4) protein contains a death domain and a kinase-like domain. IRAKs are mainly involved in toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) signaling. IRAK4 can activate NF-κB (nuclear factor κ B) and MAPK (mitogen activated protein kinase) pathways. It plays a crucial role in adaptive immunity and inflammatory responses. IRAK4 mRNA levels are higher in humans suffering from Vogt-Koyanagi-Harada (VKH) disease. Mutations in IRAK4 are associated with recurrent pyogenic bacterial infections in children.

Forme physique

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Informations légales

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Min Sun et al.
PloS one, 9(4), e93214-e93214 (2014-04-03)
To explore whether IRAK1 and IRAK4 are involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. Thirty-nine VKH patients and thirty-two healthy controls were included in this study. The mRNA levels of IRAK1 and IRAK4 from active VKH patients, inactive VKH
Ryan Ferrao et al.
Molecular cell, 55(6), 891-903 (2014-09-10)
Trans-autophosphorylation is among the most prevalent means of protein kinase activation, yet its molecular basis is poorly defined. In Toll-like receptor and interleukin-1 receptor signaling pathways, the kinase IRAK4 is recruited to the membrane-proximal adaptor MyD88 through death domain (DD)
Shyun Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(8), 5567-5572 (2002-04-18)
Toll/IL-1 receptor family members are central components of host defense mechanisms in a variety of species. One well conserved element in their signal transduction is Ser/Thr kinases, which couple early signaling events in a receptor complex at the plasma membrane
Nobutaka Suzuki et al.
Trends in immunology, 23(10), 503-506 (2002-09-26)
Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns and members of the proinflammatory interleukin-1 receptor (IL-1R) family, share homologies in their cytoplasmic domains. Engagement of members of both of these families initiates a common intracellular signaling cascade, in which MyD88
Leah Cushing et al.
The Journal of biological chemistry, 289(15), 10865-10875 (2014-02-26)
IRAK4 is a central kinase in innate immunity, but the role of its kinase activity is controversial. The mechanism of activation for IRAK4 is currently unknown, and little is known about the role of IRAK4 kinase in cytokine production, particularly

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