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H7250

Sigma-Aldrich

Histamine dihydrochloride

≥99% (TLC), powder, endogenous histamine receptor agonist

Synonyme(s) :

2-(4-Imidazolyl)ethylamine dihydrochloride

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10 MG
29,40 €
5 G
102,00 €
10 G
102,00 €
25 G
409,00 €

29,40 €


Disponible pour expédition le07 avril 2025Détails


Devis pour commande en gros

Sélectionner une taille de conditionnement

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10 MG
29,40 €
5 G
102,00 €
10 G
102,00 €
25 G
409,00 €

About This Item

Formule empirique (notation de Hill) :
C5H9N3 · 2HCl
Numéro CAS:
Poids moléculaire :
184.07
Beilstein:
3624116
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352116
eCl@ss :
32160406
ID de substance PubChem :
Nomenclature NACRES :
NA.77

29,40 €


Disponible pour expédition le07 avril 2025Détails


Devis pour commande en gros

Nom du produit

Histamine dihydrochloride, ≥99% (TLC), powder

Essai

≥99% (TLC)

Forme

powder

Couleur

white to off-white

Pf

249-252 °C (lit.)

Température de stockage

2-8°C

Chaîne SMILES 

Cl[H].Cl[H].NCCc1c[nH]cn1

InChI

1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H

Clé InChI

PPZMYIBUHIPZOS-UHFFFAOYSA-N

Informations sur le gène

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Description générale

Histamine dihydrochloride is a derivative of histamine.[1] It prevents the formation of ROS (reactive oxygen species), which inhibits the activation of T cells and natural killer cells.[2] Histamine dihydrochloride is implicated in tumor cell apoptosis.[1] It prevents the relapse of acute myeloid leukemia in patients.[3]

Application

Histamine dihydrochloride has been used:
  • as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)[4]
  • to determine its level in fish using HPLC (high performance liquid chromatography)[5]
  • to assess the tracheal response to antigens in guinea-pigs[6]

Actions biochimiques/physiologiques

Endogenous H1 and H2 histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Health hazardExclamation mark

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificats d'analyse (COA)

Lot/Batch Number

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Maternal dietary antigens and the immune response in the offspring of the guinea-pig.
Telemo E, et al.
Immunology, 62(1), 35-35 (1987)
Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia
Martner A, et al.
Expert Review of Hematology, 3(4), 381-391 (2010)
Determination of some quality criteria of cold storaged marinated anchovy under vacuum and modified atmosphere conditions
Guncsen U, et al.
Turkish Journal of Fisheries and Aquatic Sciences, 11(2), 282-291 (2011)
Histamine H4 receptor: a Novel Drug Target For Immunoregulation and Inflammation (2013)
Histamine Dihydrochloride.
Yang LPH and Perry CM.
Drugs, 71(1), 109-122 (2011)

Articles

DISCOVER Bioactive Small Molecules for Neuroscience

Questions

1–6 sur 6 questions  
  1. Is Histamine dihydrochloride H7250 traceable to SI units?

    1 réponse
    1. This product is sold by weight. It is a powder that is at least 99% pure. There is no unit value associated with this material. The 'SI' term tends to refer to serum levels as nmol/L.

      To discuss further, please navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquiries" under the Products Section with all the required information so that a member of the Technical Service team can reach out to assist further. Thank you.

      Utile ?

  2. How should Product H7250, Histamine dihydrochloride, be dissolved?

    1 réponse
    1. We test the solubility of this product in water at a concentration of 50 mg/mL. This yields a clear, colorless to faint yellow solution.

      Utile ?

  3. What is the solution stablity of Product H7250, Histamine dihydrochloride?

    1 réponse
    1. Solutions can be stored at 2-4°C for 8 weeks, and at -20°C for up to 12 months. Once thawed, solutions should be used within 6 hours or discarded. Solutions are light sensitive and need to be protected from light.

      Utile ?

  4. How should Product H7250, Histamine dihydrochloride, be stored?

    1 réponse
    1. This product is a powder and should be stored at 2-8°C, dessicated.

      Utile ?

  5. How does the storage temperature relate to shipping conditions?

    1 réponse
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Utile ?

  6. What is the Department of Transportation shipping information for this product?

    1 réponse
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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