H6541
Oncostatin M human
OSM, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
Synonyme(s) :
OSM
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About This Item
Produits recommandés
Source biologique
human
Niveau de qualité
Produit recombinant
expressed in HEK 293 cells
Pureté
≥95% (SDS-PAGE)
Forme
lyophilized powder
Puissance
≤0.1-1.5 ng/mL EC50
Qualité
endotoxin tested
Poids mol.
dimer 30 kDa (glycosylated)
Conditionnement
pkg of 5X10 μg
pkg of 10 μg
Technique(s)
cell culture | mammalian: suitable
Impuretés
≤1 EU/μg
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... OSM(5008)
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Actions biochimiques/physiologiques
Oncostatin M (OSM), LIF, G-CSF, IL-6, and CNTF are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. OSM is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. OSM is secreted by macrophages and activated T lymphocytes.
Forme physique
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Remarque sur l'analyse
The activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (humanerythroleukemic indicator cell line)
Informations légales
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Yu-Fan Chen et al.
Hepatology (Baltimore, Md.), 55(4), 1193-1203 (2011-11-19)
Liver transplantation is the only definitive treatment for end-stage cirrhosis and fulminant liver failure, but the lack of available donor livers is a major obstacle to liver transplantation. Recently, induced pluripotent stem cells (iPSCs) derived from the reprogramming of somatic
Yuxin Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(42), 16975-16980 (2013-10-02)
The activation of STAT3 by tyrosine phosphorylation, essential for normal development and for a normal inflammatory response to invading pathogens, is kept in check by negative regulators. Abnormal constitutive activation of STAT3, which contributes to the pathology of cancer and
Kasturi Ganesh et al.
Journal of immunology (Baltimore, Md. : 1950), 189(5), 2563-2573 (2012-07-31)
Monocytes and macrophages (m) are plastic cells whose functions are governed by microenvironmental cues. Wound fluid bathing the wound tissue reflects the wound microenvironment. Current literature on wound inflammation is primarily based on the study of blood monocyte-derived macrophages, cells
Nathan R West et al.
Endocrine-related cancer, 19(2), 181-195 (2012-01-24)
The most important clinical biomarker for breast cancer management is oestrogen receptor alpha (ERα). Tumours that express ER are candidates for endocrine therapy and are biologically less aggressive, while ER-negative tumours are largely treated with conventional chemotherapy and have a
Huang-Ju Tu et al.
Journal of cellular physiology, 228(5), 983-990 (2012-10-09)
Oncostatin M (OSM) belongs to IL-6 subfamily and is mostly produced by T lymphocytes. High levels of OSM are detected in the pannus of rheumatoid arthritis (RA) patients and it may arouse the inflammation responses in joints and eventually leads
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