H1791

Anti-HOXC8 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonyme(s) : Anti-HOX3A, Anti-Homeobox 3A, Anti-Homeobox C8, Anti-Hox-3.1 (mouse)
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen ~34 kDa
• Espèces réactives: human
• Concentration: ~1.0 mg/mL
• Technique(s): immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human HOXC8; western blot: 1-2 μg/mL using extracts of HEK-293T cells over expressing human HOXC8
• Numéro d'accès UniProt: P31273
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... HOXC8(3224) ; mouse ... Hoxc8(15426) ; rat ... Hoxc8(24460)

Description

Description générale

Homeobox C8 (HOXC8) is a member of homeobox (HOX) family. It is a transcription factor, expressed in neural tube, brain, breast and adult bone marrow. HOX genes consist of a highly conserved 60-amino-acid region (the homeobox) with DNA-binding activity, that contributes to their activity as transcription factors. The gene is located on human chromosome 12q13.

Immunogène

synthetic peptide corresponding to amino acids 96-110 of human HOXC8 conjugated to KLH. The corresponding sequence is identical in mouse and rat.

Application

Anti-HOXC8 antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Actions biochimiques/physiologiques

Homeobox C8 (HOXC8) is involved in cell growth, migration and metastasis of various cancers. Hox genes are important for embryonic development. Mutations in this gene are implicated in the development of cancers, such as leukemias or neoplasms of the breast, prostate, kidney, colon, skin and brain.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.