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GW21071

Sigma-Aldrich

Anti-PI3K antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β isoform

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

chicken

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

rat, mouse, human

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_006210.1

Numéro d'accès UniProt

P42338

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... PIK3CB(5291)

Immunogène

Immunogen Sequence: GI # 5453894, sequence 58-134
Recombinant phosphoinositide-3-kinase, catalytic, β polypeptide

Application

Anti-PI3K antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Actions biochimiques/physiologiques

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β isoform is an enzyme encoded by the PIK3CB gene in humans. It has been implicated as a participant in signaling pathways regulating cell growth by virtue of its activation in response to various mitogenic stimuli. PI 3-kinase exhibits different isoforms and has a define family of genes encoding distinct PI 3-kinase catalytic subunits that can associate with p85. It is commonly activated in tumors. PI3K pathway is activated in tumors and most commonly through p110α mutation or PTEN deletion.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Lan Liu et al.
Oncology letters, 14(3), 3741-3747 (2017-09-21)
Catalpol is an effective active ingredient that functions as a diuretic and laxative, and exhibits blood sugar-lowering, liver protective, anti-aging and anticancer effects. In traditional Chinese medicine, catalpol is believed to be Yin nourishing. The anticancer effect of catalpol on
Hashem A Dbouk et al.
PloS one, 8(5), e63833-e63833 (2013-06-05)
The PI3-kinase pathway is commonly activated in tumors, most often by loss of PTEN lipid phosphatase activity or the amplification or mutation of p110α. Oncogenic mutants have commonly been found in p110α, but rarely in any of the other catalytic
Dongjin Lv et al.
Molecular medicine reports, 23(3) (2021-01-27)
Long non‑coding RNAs (lncRNAs) are involved in the occurrence and progression of numerous types of cancer. The aim of the present study was to evaluate the effect of the lncRNA maternally expressed gene 3 (MEG3) on the migration and invasion of
P Hu et al.
Molecular and cellular biology, 13(12), 7677-7688 (1993-12-01)
Phosphatidylinositol 3-kinase (PI 3-kinase) has been implicated as a participant in signaling pathways regulating cell growth by virtue of its activation in response to various mitogenic stimuli. Here we describe the cloning of a novel and ubiquitously expressed human PI
Hashem A Dbouk et al.
Oncotarget, 1(8), 729-733 (2011-02-16)
The PI3K pathway is frequently activated in tumors, most commonly through p110α mutation or PTEN deletion. In contrast to p110α, p110β is oncogenic when over-expressed in the wild-type state, suggesting that its regulation by p85 is different than that of
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