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GW21024

Anti-ADCY6 antibody produced in chicken

Name: Anti-ADCY6 antibody produced in chicken
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Adenylate cyclase type 6, Anti-KIAA0422

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About This Item

Code UNSPSC :

12352203

Nomenclature NACRES :

NA.41

Source biologique

chicken

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Fabricant/nom de marque

Genway 15-288-21024

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_056085.1

Numéro d'accès UniProt

O43306

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ADCY6(112)

Immunogène

Immunogen Sequence: GI # 10181096, sequence 1-121

Recombinant adenylate cyclase 6 isoform a

Application

Anti-ADCY6 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Actions biochimiques/physiologiques

Adenylate cyclase type 6 is an enzyme encoded by the ADCY6 gene in humans. It is a critical regulator of metabolic and cardiovascular function. It is expressed principally in lipid rafts or caveolae of cardiac myocytes and other cell types. It is localized in lipid rafts of COS-7 cells (expressing caveolin-1). Both the C1 and C2 domains of AC6 play a role in targeting AC6 to lipid rafts.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Increased blood pressure and hyperdynamic cardiovascular responses in carriers of a common hyperfunctional variant of adenylyl cyclase 6.

Gary J Hodges et al.

The Journal of pharmacology and experimental therapeutics, 335(2), 451-457 (2010-08-25)

Adenylyl cyclase (ADCY) is a critical regulator of metabolic and cardiovascular function. We have identified a genetic variant (A674S) in ADCY isoform 6 (ADCY6). Subsequent studies demonstrated that the expression of this ADCY6 variant paralleled an increase in adenylyl cyclase-mediated

The C1 and C2 domains target human type 6 adenylyl cyclase to lipid rafts and caveolae.

Muthusamy Thangavel et al.

Cellular signalling, 21(2), 301-308 (2008-11-15)

Previous data has shown that adenylyl cyclase type 6 (AC6) is expressed principally in lipid rafts or caveolae of cardiac myocytes and other cell types while certain other isoforms of AC are excluded from these microdomains. The mechanism by which

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