G8764
Gc-globulin from human plasma
≥90% (SDS-PAGE), lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)
Synonyme(s) :
DBP, Group-Specific Component, Vitamin D Binding Protein
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About This Item
Produits recommandés
Source biologique
human plasma
Niveau de qualité
Essai
≥90% (SDS-PAGE)
Forme
lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)
Poids mol.
~52 kDa
Technique(s)
LC/MS: suitable
Solubilité
H2O: soluble 2 mg/mL
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... GC(2638)
Description générale
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Gc-globulin from human plasma is encoded by the gene GC, which is mapped to human chromosome 4q13.3.[1]
Application
Gc-globulin from human plasma has been used:
- as a fluorescent probe for G-actin staining[4]
- as a fluorescent probe to monitor steady-state rate of actin filament disassembly[5]
- as a calibrator for liquid chromatography with mass spectrometry (LC-MS/MS)[6]
Gc-globulin is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions.[7] It has been used to anlayze its glycosylation patterns.
Actions biochimiques/physiologiques
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Single nucleotide polymorphism in the gene GC is associated with deficiency of 25-hydroxyvitamin D [25(OH)D].[1]
Notes préparatoires
Native Gc-globulin from human plasma
Clause de non-responsabilité
Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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We have recently shown positive effects in the quality of life in autism and amyloid lateral sclerosis patients using a newly developed 25-OH vitamin D deglycosylated vitamin D binding protein complex (VitD~dgVDBP) by reducing oxidative stress. The question arises whether
K Jie et al.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 3(3), S145-S147 (1985-12-01)
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