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G4671

Sigma-Aldrich

Anti-GATA1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-ERYF1, Anti-Erythroid transcription factor 1, Anti-Globin transcription factor 1

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About This Item

Numéro MDL:
MFCD02096392
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~42 kDa

Espèces réactives

human, rat, mouse

Concentration

~1 mg/mL

Technique(s)

immunohistochemistry: 1:100-1:250
western blot: 1:500-1:1,000

Numéro d'accès UniProt

P15976

Conditions d'expédition

dry ice

Température de stockage

−20°C

Informations sur le gène

human ... GATA1(2623)
mouse ... Gata1(14460)
rat ... Gata1(25172)

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Immunogène

synthetic peptide corresponding to residues 211-225 of human GATA1.

Application

Anti-GATA1 antibody produced in rabbit is suitable for immunoblotting at a working dilution of 1:500 to 1:1000 and for immunohistochemistry at a working dilution of 1:100 to 1:250.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Actions biochimiques/physiologiques

GATA1 belongs to the GATA family of transcription factors. The encoded protein regulates erythroid development and megakaryocyte differentiation. It binds to the consensus sequence 5′-[AT]GATA[AG]-3′ within the regulatory region. Defects in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. Reduced levels of GATA1 may cause Diamond-Blackfan anemia.

Forme physique

solution in phosphate buffered saline, containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Luciana M Hollanda et al.
Nature genetics, 38(7), 807-812 (2006-06-20)
Acquired somatic mutations in exon 2 of the hematopoietic transcription factor GATA-1 have been found in individuals with Down syndrome with both transient myeloproliferative disorder and acute megakaryoblastic leukemia. These mutations prevent the synthesis of the full-length protein but allow
K E Nichols et al.
Nature genetics, 24(3), 266-270 (2000-03-04)
Haematopoietic development is regulated by nuclear protein complexes that coordinate lineage-specific patterns of gene expression. Targeted mutagenesis in embryonic stem cells and mice has revealed roles for the X-linked gene Gata1 in erythrocyte and megakaryocyte differentiation. GATA-1 is the founding
Leif S Ludwig et al.
Nature medicine, 20(7), 748-753 (2014-06-24)
Ribosomal protein haploinsufficiency occurs in diverse human diseases including Diamond-Blackfan anemia (DBA), congenital asplenia and T cell leukemia. Yet, how mutations in genes encoding ubiquitously expressed proteins such as these result in cell-type- and tissue-specific defects remains unknown. Here, we
C D Trainor et al.
Nature, 343(6253), 92-96 (1990-01-04)
Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and
Fengyun Sun et al.
Development (Cambridge, England), 137(10), 1699-1707 (2010-05-01)
The ENU-induced repro8 mutation was identified in a screen to uncover genes that control mouse gametogenesis. repro8 causes male-limited infertility, with failure of spermatocytes to exit meiotic prophase via the G2/MI transition. The repro8 mutation is in the Eif4g3 gene
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