F9052

Anti-FRS2 (SNT-1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonyme(s) : Anti-FRS1A, Anti-FRS2A, Anti-FRS2alpha, Anti-SNT, Anti-SNT-1, Anti-SNT1
• Numéro MDL: MFCD03791556
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 92-95 kDa (doublet)
• Espèces réactives: rat, mouse, human
• Technique(s): immunoprecipitation (IP): 10-20 μg using RIPA lysate of mouse NIH/3T3 cells; microarray: suitable; western blot: 1:1,000 using whole cell extracts of rat PC-12 cells or human HepG2 cells
• Numéro d'accès UniProt: Q8WU20
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... FRS2(10818) ; mouse ... Frs2(327826) ; rat ... Frs2(314850)

Description

Description générale

Fibroblast growth factor receptor substrate 2 (FRS2), also known as suc-1 associated neurotrophic factor target protein (SNT) exist in two structurally similar forms namely, FRS2a (SNT-1) and FRS-2b (SNT-2). FRS2 is characterized with a consensus myristylation sequence, involved in its recruitment to the cell membrane 4 and a putative phosphotyrosine binding (PTB) domain in its amino-terminus.

Immunogène

synthetic peptide corresponding to human FRS2 sequence, (amino acids 487-505). The corresponding sequence is identical in Xenopus and differs from the respective human and mouse FRS2β sequences by 2 and 3 amino acids, respectively.

Actions biochimiques/physiologiques

Fibroblast growth factors (FGF) receptor substrate (FRS) functions as a lipid-anchored docking protein that is tyrosine phosphorylated and recruited to FGFR upon FGF stimulation. fibroblast growth factor receptor substrate 2 (FRS2) plays an important role in linking fibroblast growth factor (FGF) and nerve growth factor (NGF) with the Ras/ mitogen-activated protein kinases (MAPKs) signaling pathway, thus relaying information from the cell surface to the nucleus. FRS2 proteins are tyrosine phosphorylated in response to activation of the RET receptor, a tyrosine kinase that functions as the signal transducing receptor for the glial cell line-derived neurotrophic factor (GDNF).

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable