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E4642
(±)-Epinephrine hydrochloride
≥98% (TLC), powder, adrenergic receptor agonist
Synonyme(s) :
(±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
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About This Item
Formule empirique (notation de Hill):
C9H13NO3 · HCl
Numéro CAS:
Poids moléculaire :
219.67
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Nom du produit
(±)-Epinephrine hydrochloride,
Niveau de qualité
Solubilité
H2O: 50 mg/mL
Température de stockage
2-8°C
Chaîne SMILES
OC(CNC)C1=CC=C(O)C(O)=C1.Cl
InChI
1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
Clé InChI
ATADHKWKHYVBTJ-UHFFFAOYSA-N
Informations sur le gène
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)
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Description générale
Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system.[1] It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors.[2] Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.[3]
Application
(±)-Epinephrine hydrochloride has been used:
- in the induction of renalase expression in Human renal proximal tubular epithelial cells[4]
- in the infusion studies to test its effect on heart rate and eye temperature measurements in bull[5]
- as a medium supplement for the stimulation of endothelial progenitor cells[6]
Actions biochimiques/physiologiques
Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility.[3] It is used in the treatment of acute anaphylaxis.[7] Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.[8]
Adrenergic receptor agonist.
Autres remarques
The ratio of +/- adrenaline is not determined.
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organes cibles
Respiratory system
Code de la classe de stockage
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Adrenaline, cardiac arrest, and evidence based medicine.
Rainer TH and Robertson CE
Emergency Medicine Journal : EMJ, 13(4), 234-237 (1996)
Effects of an epinephrine infusion on eye temperature and heart rate variability in bull calves
Stewart M, et al.
Journal of Dairy Science, 93(11), 5252-5257 (2010)
Epinephrine: the drug of choice for anaphylaxis-a statement of the World Allergy Organization
Kemp SF, et al.
The World Allergy Organization journal, 1(2), S18-S18 (2008)
Sympathetic predominance is associated with impaired endothelial progenitor cells and tunneling nanotubes in controlled-hypertensive patients
de Cavanagh EAMV, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 307, H207?H215-H207?H215 (2014)
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est ce que l'epinephrine de degrade a 37C et est ce qu'il est reversible?
1 réponse-
Utile ?
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Can it be stored at -20C
1 réponse-
The recommended storage temperature for this product is 2-8°C. In general, powder materials are not affected by freezer storage, however, this item has not been tested under these storage conditions.
Utile ?
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Hi, Do you have the ratio/ amount of D- and L-adrenaline in this product?
1 réponse-
The ratio of +/- adrenaline is not determined.
Utile ?
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