E2250

Ellagic acid

≥95% (HPLC), powder, from tree bark

• Synonyme(s) : 4,4′,5,5′,6,6′-Hexahydroxydiphenic acid 2,6,2′,6′-dilactone, Alizarin Yellow, Benzoaric acid, Elagostasine, Eleagic acid, Gallogen, Lagistase
• Formule empirique (notation de Hill) : C₁₄H₆O₈
• Numéro CAS: 476-66-4
• Poids moléculaire : 302.19
• UNSPSC Code: 12352205
• NACRES: NA.77
• PubChem Substance ID: 24894460
• EC Number: 207-508-3
• Beilstein/REAXYS Number: 47549
• MDL number: MFCD00006914

Propriétés

• biological source: tree bark
• Quality Segment: 200
• assay: ≥95% (HPLC)
• form: powder
• shelf life: 5 yr
• solubility: 1 M NaOH: 10 mg/mL
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• SMILES string: Oc1cc2C(=O)Oc3c(O)c(O)cc4C(=O)Oc(c1O)c2-c34
• InChI: 1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H
• InChI key: AFSDNFLWKVMVRB-UHFFFAOYSA-N
• Gene Information: human ... CSK(1445), DYRK1A(1859), GSK3B(2932), SRC(6714) ; rat ... Lyn(81515), Syk(25155)

Description

General description

Ellagic acid is a naturally occurring phenolic acid in many fruits and vegetables, as a secondary plant metabolite. It is commonly found in green tea, pomegranate, strawberries, blackberries, raspberries, and walnuts.[1]

Application

Ellagic acid has been used:

• to study the metabolism of dietary phenolic acids by Lactobacillus plantarum CECT 748T
• as a potential substrate for the high production of Lactobacillus plantarum tannase[2]
• as a standard in the study to examine the phenolic components and anti-oxidant activity of nettle[3]
• to study the links between dietary ellagic acid and epigenetic modulation of adipogenesis[4]

Biochem/physiol Actions

Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase. Used for the assay of factor XIIa in plasma. Contact activation in blood coagulation.

Ellagic acid has been found to exhibit antioxidant activity by virtue of having an inhibitory effect on the oxidation of low-density lipoproteins. This makes them have a cardioprotective effect on humans. In addition, it shows anticarcinogenic, antifibrotic, antiplasmodial, apoptotic, and chemopreventive activities as well.[1]

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves