D7692

Diethylumbelliferyl phosphate

≥98% (HPLC), cholesterol esterase inhibitor, oil

• Synonyme(s) : DEUP, UBP
• Formule empirique (notation de Hill) : C₁₄H₁₇O₆P
• Numéro CAS: 897-83-6
• Poids moléculaire : 312.25
• UNSPSC Code: 12352200
• PubChem Substance ID: 24894155
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: oil

Propriétés

• Nom du produit: Diethylumbelliferyl phosphate, ≥98% (HPLC), oil
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: oil
• color: colorless to yellow
• solubility: DMSO: >5 mg/mL
• storage temp.: −20°C
• SMILES string: CCOP(=O)(OCC)Oc1ccc2C(C)=CC(=O)Oc2c1
• InChI: 1S/C14H17O6P/c1-4-17-21(16,18-5-2)20-11-6-7-12-10(3)8-14(15)19-13(12)9-11/h6-9H,4-5H2,1-3H3
• InChI key: GHGRYKAFUNNHBG-UHFFFAOYSA-N

Description

Application

Diethylumbelliferyl phosphate has been used as a lipase inhibitor to treat wild-type myeloblasts for in vitro neutrophil differentiation assays.

Biochem/physiol Actions

Diethylumbelliferyl phosphate (DEUP), an organophosphate does not block protein kinase activity A in vitro.[1]

Diethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor. It blocks steroidogenesis primarily by preventing cholesterol transport into the mitochondria of steroidogenic cells. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. IC₅₀ = 11.6 μM.

Informations sur la sécurité

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges