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COO/COA

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D7412

(±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide

Name: (±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide
Brand: SIGMA

Synonyme(s) :

(±)-DOB hydrobromide

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About This Item

Formule empirique (notation de Hill):

C₁₁H₁₆BrNO₂ · HBr

Numéro CAS:

53581-53-6

Poids moléculaire :

355.07

Numéro MDL:

MFCD00069251

Code UNSPSC :

12352116

ID de substance PubChem :

24894134

Nomenclature NACRES :

NA.77

Contrôle du médicament

USDEA Schedule I; Home Office Schedule 1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
veterinary

Chaîne SMILES

Br[H].COc1cc(CC(C)N)c(OC)cc1Br

Clé InChI

KOUBEZAODVTFTG-UHFFFAOYSA-N

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Actions biochimiques/physiologiques

Hallucinogenic; 5-HT₂ serotonin receptor agonist.

Pictogrammes

GHS06

Mention d'avertissement

Danger

Mentions de danger

H302,H310 + H330

Conseils de prudence

P260 - P262 - P280 - P301 + P312 - P302 + P352 + P310 - P304 + P340 + P310

Classification des risques

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 4 Oral

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Selectivity of serotonergic drugs for multiple brain serotonin receptors. Role of [3H]-4-bromo-2,5-dimethoxyphenylisopropylamine ([3H]DOB), a 5-HT2 agonist radioligand.

M Titeler et al.

Biochemical pharmacology, 36(19), 3265-3271 (1987-10-01)

The affinities of putative serotonin receptor agonists and antagonists for 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT2 receptors were assayed using radioligand binding assays. The 5-HT1 sites were labeled with the agonist radioligands [3H]-8-hydroxy-2-(di-n-propylamino)-tetralin [3H]-8-OH-DPAT, [3H]-5-HT, and [3H]mesulergine. The 5-HT2 receptor was

Potent agonist activity of DOB at 5-HT2 receptors in guinea pig trachea.

W A Heller et al.

European journal of pharmacology, 138(1), 115-117 (1987-06-12)

DOB, 4-bromo-2,5-dimethyloxyamphetamine, a potent hallucinogen, displays high affinity for the 5-HT2 receptor in binding assays. Since 5-HT contractile responses in guinea pig trachea are mediated by 5-HT2 receptors, we assessed the activity of DOB and related analogs in this preparation.

Study on metabolites of 2,5-dimethoxy-4-bromamphetamine (DOB) in human urine using gas chromatography-mass spectrometry.

Katerina Beránková et al.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 149(2), 465-468 (2006-04-08)

The study of the biotransformation of a new synthetic drug 2,5-dimethoxy-4-bromamphetamine (DOB) and identification of its metabolites in urine of a poisoned person is described using gas chromatography mass spectrometry (GC-MS) with various ways of derivatization. It has been confirmed

'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines.

Danielle M Schultz et al.

Bioorganic & medicinal chemistry, 16(11), 6242-6251 (2008-05-10)

Phenylalkylamines that possess conformationally rigidified furanyl moieties in place of alkoxy arene ring substituents have been shown previously to possess the highest affinities and agonist functional potencies at the serotonin 5-HT(2A) receptor among this chemical class. Further, affinity declines when

Nonfatal and fatal DOB (2,5-dimethoxy-4-bromoamphetamine) overdose.

Marie Balíková

Forensic science international, 153(1), 85-91 (2005-06-28)

2,5-Dimethoxy-4-bromoamphetamine (DOB) is a strongly acting hallucinogen with an estimated effective dose of 2 mg for an 80 kg man. The case of two men who ingested a new "hallucinogen LSD-like" designer drug is reported here. They experienced intense hallucinations

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