D3630

Diphenhydramine hydrochloride

≥98% (HPLC), H1 histamine receptor antagonist, powder

• Synonyme(s) : 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride
• Formule empirique (notation de Hill) : C₁₇H₂₁NO · HCl
• Numéro CAS: 147-24-0
• Poids moléculaire : 291.82
• NACRES: NA.77
• PubChem Substance ID: 24277771
• UNSPSC Code: 12352116
• EC Number: 205-687-2
• MDL number: MFCD00012479
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Nom du produit: Diphenhydramine hydrochloride, ≥98% (HPLC)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• originator: Johnson & Johnson
• SMILES string: Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2
• InChI: 1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
• InChI key: PCHPORCSPXIHLZ-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269)

Description

Application

Diphenhydramine hydrochloride has been used:
as a reference compound to study the long duration of action of antihistamine bilastine in vivo
to detect its embryotoxicity by embryonic stem cell test (EST) using cardiomyocyte differentiation and osteoblasts differentiation[1]
as an antihistamine in experimental studies

Biochem/physiol Actions

H1 histamine receptor antagonist
Diphenhydramine hydrochloride (DPH) is an antihistaminic agent that relieves symptoms of hypersensitive reactions. It exhibits antimuscarinic and marked sedative effects. DPH is also used to prevent nausea, vomiting and vertigo of various causes. In addition, it acts as a potential therapeutic for insomnia.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves