D2022
5,6-Dihydrothymidine
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About This Item
Formule empirique (notation de Hill):
C10H16N2O5
Numéro CAS:
Poids moléculaire :
244.24
Numéro MDL:
Code UNSPSC :
12352204
Température de stockage
−20°C
Chaîne SMILES
CC1CN(C2CC(O)C(CO)O2)C(=O)NC1=O
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Efficiency of incision of an AP site within clustered DNA damage by the major human AP endonuclease.
Marie-Hélène David-Cordonnier et al.
Biochemistry, 41(2), 634-642 (2002-01-10)
A major DNA lesion induced by ionizing radiation and formed on removal of oxidized base lesions by various glycosylases is an apurinic/apyrimidinic site (AP site). The presence of an AP site within clustered DNA damage, induced following exposure to ionizing
M A Chaudhry et al.
Journal of molecular biology, 249(5), 914-922 (1995-06-23)
Energy deposition by ionizing radiation can lead to the formation of clustered DNA damage, i.e. more than one lesion situated within a helical turn of DNA. Among the postulated lesions are those characterized by damaged bases and abasic sites on
E A Furlong et al.
Biochemistry, 25(15), 4344-4349 (1986-07-29)
5,6-Dihydrothymidine (dDHT) is a derivative thymidine formed during gamma-irradiation. This paper demonstrates the conditions under which dDHT is formed in solutions of DNA and that dDHT is produced in the DNA of HeLa cells during gamma-irradiation. The product of dDHT
M Weinfeld et al.
Nucleic acids research, 21(3), 621-626 (1993-02-11)
Stacking between aromatic amino acids and nucleic acid bases may play an important role in the interaction of enzymes with nucleic acid substrates. In such circumstances, disruption of base aromaticity would be expected to decrease enzyme activity on the modified
K A Tallman et al.
Journal of the American Chemical Society, 123(22), 5181-5187 (2001-07-18)
5,6-Dihydrothymidin-5-yl (1) was independently generated in a dinucleotide from a phenyl selenide precursor (4). Under free radical chain propagation conditions, the products resulting from hydrogen atom donation and radical-pair reaction are the major observed products in the absence of O(2).
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