C9750

β-Carotene

synthetic, ≥93% (UV), powder

• Synonyme(s) : β,β-Carotene, Provitamin A
• Formule empirique (notation de Hill) : C₄₀H₅₆
• Numéro CAS: 7235-40-7
• Poids moléculaire : 536.87
• Beilstein: 1917416
• Numéro CE : 230-636-6
• Numéro MDL: MFCD00001556
• Code UNSPSC : 12352205
• ID de substance PubChem : 24893189
• Nomenclature NACRES : NA.79

Propriétés

• Source biologique: synthetic
• Essai: ≥93% (UV)
• Forme: powder
• Puissance: ~1,600,000 units vitamin A per g
• Couleur: dark red to brown
• Pf: 178-179 °C
• Solubilité: hexane: 1.1 mg/mL; DMSO: 30 μg/mL
• Température de stockage: −20°C
• Chaîne SMILES: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)(C)CCC1
• InChI: 1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+
• Clé InChI: OENHQHLEOONYIE-JLTXGRSLSA-N

Description

Description générale

Carotenoids are an important class of naturally occurring pigments found in fruits and vegetables. Among the carotenoids, β-carotene has the greatest provitamin A potential and functions to reduce the risk of cancer, cardiovascular diseases and macular degeneration. Low water solubility and poor chemical stability attributes to low absorption of β-carotene from food. β-carotene along with digestible lipids enriches its bio accessibility. Emulsions or nano emulsions encapsulates effectively delivers lipophilic β-carotene and increases its bioavailability.[1] β-carotene has anti-oxidant potential and reduces noise induced hearing loss and progression of macular degeneration.[2]

Application

β-carotene has been used:

• to generate nano emulsions to evaluate their bioavailability potential[1]
• as a standard, for β-carotene evaluation in blood and skin samples using high performance liquid chromatography (HPLC),[3]
• as a dietary supplement of vitamin-A in young rats by HPLC[4]
• as a dietary supplement in mice to reduce hearing loss and hair cell damage[2]

Actions biochimiques/physiologiques

The most important of the provitamins A, β-carotene can be classified as an antioxidant due to its inhibition of radical initiated peroxidation in vitro. However, in vivo it appears to act either as an antioxidant or a prooxidant depending on cellular environment. It reduces the incidence of many cancers, but enhances lung cancer incidence in smokers.

The most important of the provitamins A.

Conditionnement

Packaged in serum vials.

Attention

Purchase minimum quantity required. Discard one month after opening.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 217.9 °F - closed cup
• Point d'éclair (°C): 103.3 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Gloves