C9229
Monoclonal Anti-COX I antibody produced in mouse
clone AS70, purified immunoglobulin, buffered aqueous solution
Synonyme(s) :
Anti-Cyclooxygenase I
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About This Item
Source biologique
mouse
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
AS70, monoclonal
Forme
buffered aqueous solution
Espèces réactives
human
Concentration
1 mg/mL
Technique(s)
indirect ELISA: suitable
western blot: suitable
Isotype
IgG1
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... PTGS1(5742)
Immunogène
recombinant full length human COX I, 599 amino acids.
Application
Monoclonal Anti-COX I antibody produced in mouse is suitable for ELISA and western blotting. It was used to detect mitochondrial cytochrome c oxidase protein markerin homogenate and lipid droplet fractions isolated from L-cells by western blot analysis.
Actions biochimiques/physiologiques
COX-I, an isoform of COX enzyme with 599 amino acid residues, catalyzes the conversion of arachinodate to prostaglandin H2. It is expressed mainly in the gut for the production of prostaglandins, which inhibit gastric secretion. It is involved in the regulation of homeostatic functions throughout the body, such as vascular hemostasis, renal blood flow, and maintenance of glomerular function. It is a target of NSAID (non-steroidal anti-inflammatory drugs) such as aspirin. COX-I can be induced by IL-β and other cytokines in monocytes, macrophages, and other cells as part of the inflammatory response.
Forme physique
Solution in phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
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Physiology of the mesangial cell.
P Mené et al.
Physiological reviews, 69(4), 1347-1424 (1989-10-01)
R Langenbach et al.
Cell, 83(3), 483-492 (1995-11-03)
Cyclooxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin biosynthesis and the target enzymes for the widely used nonsteroidal anti-inflammatory drugs. To study the physiological roles of the individual isoforms, we have disrupted the mouse Ptgs1 gene
G P O'Neill et al.
Molecular pharmacology, 45(2), 245-254 (1994-02-01)
Human prostaglandin G/H synthase (hPGHS)-1 and hPGHS-2, key enzymes in the formation of prostanoids from arachidonic acid, were expressed at high levels in COS-7 cells using a T7 RNA polymerase/vaccinia virus expression system. The open reading frame of hPGHS-2 cloned
G P O'Neill et al.
FEBS letters, 330(2), 156-160 (1993-09-13)
The rate-limiting step in the formation of prostanoids is the conversion of arachidonic acid to prostaglandin H2 by cyclooxygenase, also known as prostaglandin G/H synthase/cyclooxygenase. Two forms of cyclooxygenase have been characterized: a ubiquitously expressed form (COX-1) and a recently
C D Funk et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 5(9), 2304-2312 (1991-06-01)
Platelets metabolize arachidonic acid to thromboxane A2, a potent platelet aggregator and vasoconstrictor compound. The first step of this transformation is catalyzed by prostaglandin (PG) G/H synthase, a target site for nonsteroidal antiinflammatory drugs. We have isolated the cDNA for
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