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C8990

Sp-8-pCPT-cAMPS

Name: Sp-8-pCPT-cAMPS
Brand: SIGMA

≥98% (HPLC), solid

Synonyme(s) :

8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic monophosphorothioate, Sp-isomer sodium salt

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About This Item

Formule empirique (notation de Hill):

C₁₆H₁₄ClN₅O₅PS₂Na

Numéro CAS:

129693-13-6

Poids moléculaire :

509.86

Numéro MDL:

MFCD04113743

Code UNSPSC :

12352200

ID de substance PubChem :

24724452

Pureté

≥98% (HPLC)

Forme

solid

Conditionnement

vial of 5 μmol

Solubilité

H₂O: >1 mg/mL

Conditions d'expédition

dry ice

Température de stockage

−70°C

Chaîne SMILES

[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

Description générale

Sp-8-pCPT-cAMPS is a nonhydrolyzable analog of cAMP with a p-chlorophenylthio moiety.

Application

Sp-8-pCPT-cAMPS has been used as an agonist for protein kinase A. It has also been used in the inhibition of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) in oligosphere cultures.

Actions biochimiques/physiologiques

Sp-8-pCPT-cAMPS impairs PIP2 production by phosphatidylinositol 4-phosphate 5-kinase (PIP5K) inhibition. It may be involved in promoting remyelination in astrocytes and neurons. The lipophilicity feature of Sp-8-pCPT-cAMPS aids its cell entry for mediating remyelination. It may play a role in lowering Leishmania proliferation in in vitro studies.

Selective cAMP-dependent protein kinase (PKA) activator.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression.

Chunyu Zeng et al.

Journal of hypertension, 27(5), 1033-1041 (2009-03-19)

Vascular smooth muscle cell (VSMC) proliferation is central to the development of vascular diseases, including hypertension, which is regulated by numerous hormones and humoral factors. Our previous study showed that the stimulatory effect of norepinephrine on VSMC proliferation is inhibited

Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS.

Hyun Kyoung Lee et al.

Neuron, 85(6), 1227-1243 (2015-03-11)

Wnt signaling plays an essential role in developmental and regenerative myelination of the CNS; however, contributions of proximal regulators of the Wnt receptor complex to these processes remain undefined. To identify components of the Wnt pathway that regulate these processes

Evaluation of Modulators of cAMP-Response in Terms of Their Impact on Cell Cycle and Mitochondrial Activity of Leishmania donovani.

Amrita Saha et al.

Frontiers in pharmacology, 11, 782-782 (2020-07-17)

With the identification of novel cAMP binding effector molecules in Trypanosoma, the role of cAMP in kinetoplastida parasites gained an intriguing breakthrough. Despite earlier demonstrations of the role of cAMP in the survival of Leishmania during macrophage infection, there is

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