C6617

CBIQ

≥98% (HPLC), solid

• Synonyme(s) : 4-Chlorobenzo[f]isoquinoline
• Formule empirique (notation de Hill): C₁₃H₈NCl
• Numéro CAS: 32081-28-0
• Poids moléculaire : 213.66
• Numéro MDL: MFCD02179769
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724450
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Couleur: off-white
• Solubilité: DMSO: 15 mg/mL
• Chaîne SMILES: Clc1nccc2c1ccc3ccccc23
• InChI: 1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H
• Clé InChI: SHQLTRRYZVBEMR-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.

Caractéristiques et avantages

This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H301,H315,H318,H335
• Conseils de prudence: P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Classification des risques: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges