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C6417

Sigma-Aldrich

Monoclonal Anti-Cytokeratin Peptide 7 antibody produced in mouse

clone LDS-68, ascites fluid

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About This Item

Numéro MDL:
MFCD00162253
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

ascites fluid

Type de produit anticorps

primary antibodies

Clone

LDS-68, monoclonal

Contient

15 mM sodium azide

Espèces réactives

human

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1:200 using formalin-fixed, paraffin-embedded sections of human and animal tissue
microarray: suitable
western blot: suitable

Isotype

IgG1

Numéro d'accès UniProt

P08729

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... KRT7(3855)

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Description générale

Keratin, type II cytoskeletal 7 is a protein encoded by the KRT7 gene in humans. It is also known as cytokeratin-7 (CK-7), keratin-7 (K7), sarcolectin (SCL) and K2C7. Keratin 7 is a type II keratin and is a member of the keratin gene family. It is found on chromosome 12. It is specifically expressed in the simple epithelia lining of the internal organs and in the gland ducts as well as blood vessels.
Monoclonal anti-Cytokeratin Peptide 7 (mouse IgG1 isotype) is derived from the hybridoma produced the fusion of mouse myeloma cells and splenocytes of an immunized mouse. Cytokeratins are the intermediate filaments of endocrine cells. These proteins belongs to the intermediate filament (10 nm) superfamily of cytoskeletal proteins. Cytokeratin 7 (CK 7/ KRT7) is a low molecular weight cytokeratin. It is present in epithelial tissues of lung, breast and ovary.

Spécificité

The antibody reacts specifically with most simple epithelia but shows no reaction with epithelial cells in the intestine or in the stomach.

Immunogène

cytoskeletal preparation of the RT4 human bladder carcinoma cell line.

Application

Monoclonal Anti-Cytokeratin Peptide 7 antibody produced in mouse has been used in:
  • immunohistochemical staining
  • western blotting
  • immunohistochemistry
  • immunofluorescence.

Actions biochimiques/physiologiques

Cytokeratins may play an important role in transhepatic transport and canalicular secretion. Cytokeratin 7 (CK 7/ KRT7) only stains bile ducts in normal liver, hence it is considered as “bile duct keratin”. CK 7 is widely used in surgical pathology. It acts as a specific marker for mammary and extramammary Paget′s disease.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Yoshiyuki Kasai et al.
Regenerative therapy, 4, 71-77 (2016-03-24)
Autologous oral mucosal epithelial cell sheets have been used for treating epithelial defects such as cornea and esophagus. The cell source of patients' oral mucosal epithelial cell sheet should be examined in normality because it has individual difference. In this
Immunohistology of endocrine tumors
Diagnostic Immunohistochemistry (Masson Publishing), 291-339 (2010)
Brush biopsy of human oral mucosal epithelial cells as a quality control of the cell source for fabrication of transplantable epithelial cell sheets for regenerative medicine
Kasai Y, et al.
Regenerative therapy, 4, 71-77 (2016)
M Rosenberg et al.
Cytogenetics and cell genetics, 57(1), 33-38 (1991-01-01)
We have localized the genes which encode the human type II epidermal keratins K5, K6a, and K6b and the simple epithelial keratin K7 (KRT5, KRT6A, KRT6B, and KRT7, respectively) to chromosome 12 using Southern blot analysis of somatic cell hybrids.
Role of cytokeratin intermediate filaments in transhepatic transport and canalicular secretion
Kawahara H, et al.
Hepatology, 11(3), 435-448 (1990)
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