C2247

CPPHA

≥98% (HPLC)

• Synonyme(s) : N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide, N-[4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
• Formule empirique (notation de Hill): C₂₂H₁₅ClN₂O₄
• Numéro CAS: 693288-97-0
• Poids moléculaire : 406.82
• Numéro MDL: MFCD12912405
• Code UNSPSC : 12352209
• ID de substance PubChem : 329774983
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Solubilité: DMSO: >20 mg/mL
• Auteur: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Température de stockage: −20°C
• Chaîne SMILES: Oc1ccccc1C(=O)Nc2ccc(Cl)cc2CN3C(=O)c4ccccc4C3=O
• InChI: 1S/C22H15ClN2O4/c23-14-9-10-18(24-20(27)17-7-3-4-8-19(17)26)13(11-14)12-25-21(28)15-5-1-2-6-16(15)22(25)29/h1-11,26H,12H2,(H,24,27)
• Clé InChI: UFOUABRZSDGGAZ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It has no agonist activity alone, but reduces threshold response and shifts dose-response curves to glutamate, quisqualate, and DHPG by 4- to 7-fold to the left in recombinant CHO cells expressing human or rat mGluR5.

Caractéristiques et avantages

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This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H410
• Conseils de prudence: P273 - P501
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable