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B9804

Sigma-Aldrich

Anti-Bcl-2 antibody, Mouse monoclonal

clone 10C4, purified from hybridoma cell culture

Synonyme(s) :

Anti-BCL-2

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About This Item

Numéro MDL:
MFCD00239644
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

10C4, monoclonal

Forme

buffered aqueous solution

Poids mol.

antigen 26 kDa

Espèces réactives

rat, mouse

Concentration

~2 mg/mL

Technique(s)

microarray: suitable
western blot: 2-10 μg/mL using rat osteosarcoma ROS cell extract

Isotype

IgG1

Numéro d'accès UniProt

P10417

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Bcl2(12043)
rat ... Bcl2(24224)

Spécificité

The epitope recognized by the antibody resides within amino acids 61-76 of the mouse Bcl-2 protein.

Immunogène

synthetic peptide corresponding to amino acids 61-76 of the mouse Bcl-2 sequence, conjugated to KLH.

Forme physique

Solution in phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Stockage et stabilité

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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María L Escobar et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 67(12), 873-889 (2019-10-05)
Oocyte cell death is a normal process in the mammalian ovary during follicular growth. Recent reports have demonstrated the presence of pro-apoptotic and pro-autophagic proteins during oocyte elimination. The goal of this study was to identify the interactions between proteins
Wanqi Huang et al.
Cell death & disease, 13(1), 17-17 (2021-12-22)
Impaired autophagy and excessive apoptosis disrupt cellular homeostasis and contribute to neural tube defects (NTDs), which are a group of fatal and disabling birth defects caused by the failure of neural tube closure during early embryonic development. However, the regulatory
Yue Li et al.
Molecular therapy. Nucleic acids, 35(2), 102163-102163 (2024-03-28)
Anorectal malformations (ARMs) are congenital diseases that lead to postoperative fecal incontinence, constipation, and soiling, despite improvements in surgery; however, their pathological mechanisms remain unclear. Here, we report the role of microRNA-141-3p in maintaining homeostasis between apoptosis and autophagy in
Elena Piegari et al.
Scientific reports, 10(1), 12250-12250 (2020-07-25)
Cardiotoxicity remains a serious problem in anthracycline-treated oncologic patients. Therapeutic modulation of microRNA expression is emerging as a cardioprotective approach in several cardiovascular pathologies. MiR-34a increased in animals and patients exposed to anthracyclines and is involved in cardiac repair. In
Wenfei Zhao et al.
Oncology letters, 18(5), 4613-4620 (2019-10-16)
The present study aimed to investigate the association between microRNA-152 and cisplatin resistance in non-small cell lung cancer. A549 and cisplatin-resistant A549 cells (A549/cis) were maintained in vitro. Reverse transcription-quantitative PCR (RT-qPCR) was performed to analyze differences in microRNA-152 levels
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