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Merck
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Principaux documents

B9684

Sigma-Aldrich

Anti-Brn3a antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-FLJ13449, Anti-OCT-T1, Anti-RDC1

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About This Item

Numéro MDL:
MFCD02262629
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 42.9 kDa

Espèces réactives

human

Réactivité de l'espèce (prédite par homologie)

mouse

Technique(s)

immunocytochemistry: 1:200-1:1000
immunohistochemistry (frozen sections): 1:200-1:1000
western blot: 1:200-1:1000

Numéro d'accès UniProt

Q01851

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... POU4F1(5457)
mouse ... Pou4f1(18996)
rat ... Pou4f1(114503)

Description générale

Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Immunogène

POU4F1 / BRN3A antibody was raised against synthetic peptide (aa 141-157, AGGGGAHDGPGGGGGPG) corresponding to human Brn3a (BSA conjugated). Percent identity by BLAST analysis: Human (100%); Mouse (94%); Drosophila (82%).

Epitope
aa141-157

Forme physique

Supplied in phosphate buffered saline, pH 7.4

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Brenna Krieger et al.
PloS one, 12(7), e0180091-e0180091 (2017-07-29)
The retina communicates with the brain using ≥30 parallel channels, each carried by axons of distinct types of retinal ganglion cells. In every mammalian retina one finds so-called "alpha" ganglion cells (αRGCs), identified by their large cell bodies, stout axons
Peter Stacey et al.
SLAS discovery : advancing life sciences R & D, 23(6), 585-596 (2018-03-17)
Screening against a disease-relevant phenotype to identify compounds that change the outcome of biological pathways, rather than just the activity of specific targets, offers an alternative approach to find modulators of disease characteristics. However, in pain research, use of in
RAGE and its ligand amyloid beta promote retinal ganglion cell loss following ischemia-reperfusion injury.
Seyed Hosseini Fin, et al.
Frontiers in Cellular Neuroscience, 17, 1156084-1156084 (2023)
Fuxin Shi et al.
The European journal of neuroscience, 26(11), 3016-3023 (2007-11-17)
In mammals, hair cells and auditory neurons lack the capacity to regenerate, and damage to either cell type can result in hearing loss. Replacement cells for regeneration could potentially be made by directed differentiation of human embryonic stem (hES) cells.
Hans Jürgen Wester et al.
Theranostics, 5(6), 618-630 (2015-04-01)
Chemokine ligand-receptor interactions play a pivotal role in cell attraction and cellular trafficking, both in normal tissue homeostasis and in disease. In cancer, chemokine receptor-4 (CXCR4) expression is an adverse prognostic factor. Early clinical studies suggest that targeting CXCR4 with

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