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B3063

Sigma-Aldrich

BI-78D3

≥98% (HPLC)

Synonyme(s) :

4-(2,3-Dihydrobenzol[b][1,4]dioxin-6-yl)-5-(5-nitrothiazol-2-ylthio)-4H-1,2,4-triazol-3-ol

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About This Item

Formule empirique (notation de Hill):
C13H9N5O5S2
Numéro CAS:
883065-90-5
Poids moléculaire :
379.37
Numéro MDL:
MFCD12912396
Code UNSPSC :
12352200
ID de substance PubChem :
329773213

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

tan

Solubilité

DMSO: >10 mg/mL

Température de stockage

−20°C

Chaîne SMILES 

Oc1nnc(Sc2ncc(s2)[N+]([O-])=O)n1-c3ccc4OCCOc4c3

InChI

1S/C13H9N5O5S2/c19-11-15-16-12(25-13-14-6-10(24-13)18(20)21)17(11)7-1-2-8-9(5-7)23-4-3-22-8/h1-2,5-6H,3-4H2,(H,15,19)

Clé InChI

QFRLDZGQEZCCJZ-UHFFFAOYSA-N

Actions biochimiques/physiologiques

BI-78D3 is a substrate competitive inhibitor of JNK. JNK′s binds to JNK-interacting protein-1 (JIP1) (scaffolding protein) through high affinity D-domain on JIP1. This interaction is needed to place JNK next to target protein. BI-78D3 is a mimetic of a critical peptide structure of JIP1 which binds to JNK away from ATP binding domain preventing JIP1 JNK interaction thus acting as a substrate competitive inhibitor both in vitro and in vivo. The compound represents a growing number of modern kinase inhibitors acting at protein protein interacting areas (scaffolding) rather than ATP binding pockets.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Mai Badarni et al.
JCI insight, 5 (2019-03-13)
AXL overexpression is a common resistance mechanism to anti-cancer therapies, including the resistance to BYL719 (Alpelisib) - the p110α isoform specific inhibitor of phosphoinositide 3-kinase (PI3K) - in esophagus and head and neck squamous cell carcinoma (ESCC, HNSCC respectively). However
Jianxin Zhang et al.
Experimental and therapeutic medicine, 14(6), 5445-5451 (2017-12-30)
Paeoniflorin (PAE), a principal bioactive component of
Yi Li et al.
Biomolecules & therapeutics, 26(5), 458-463 (2017-11-14)
The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. To discover the inhibitors of JNK-JIP1
Lu Wang et al.
Molecular and cellular endocrinology, 518, 110991-110991 (2020-08-26)
The function of the gonadotropin-releasing hormone (GnRH) neuron is critical to maintain reproductive function and a significant decrease in GnRH can lead to disorders affecting fertility, including hypogonadotropic hypogonadism. Spexin (SPX) is a novel hypothalamic neuropeptide that exerts inhibitory effects
Xiong Xiao et al.
Cell discovery, 5, 2-2 (2019-01-10)
The limited number of human hematopoietic stem cells (HSCs) has restrained their widespread clinical application. Despite great efforts in recent years, the in vitro expansion of HSCs remains a challenge due to incomplete understanding of the signaling networks underlying HSC
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