AV53669
Anti-FGFR1OP (AB1) antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
Anti-FGFR1 oncogene partner, Anti-FOP
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
41 kDa
Espèces réactives
human
Concentration
0.5 mg - 1 mg/mL
Technique(s)
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... FGFR1OP(11116)
Description générale
FGFR1 oncogene partner is a protein encoded by the FGFR1OP gene in humans. The fibroblast growth factor receptor 1 (FGFR1) oncogene partner called FOP is a centrosomal protein that is involved in the anchoring of microtubules (MTS) to subcellular structures.
Immunogène
Synthetic peptide directed towards the N terminal region of human FGFR1OP
Application
Anti-FGFR1OP (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.
Actions biochimiques/physiologiques
FGFR1OP (FGFR1 oncogene partner)/FOP encodes a hydrophilic centrosomal protein predominantly expressd in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis and pancreas. It interacts with EB1 and facilitates the microtubules anchoring to the centrosomes. It plays an important role in normal proliferation and differentiation of the erythroid lineage. Attenuation of Fgfr1 disrupts cochlear hair cell formation.
Séquence
Synthetic peptide located within the following region: FLQFFNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLE
Forme physique
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring.
Xiumin Yan et al.
Molecular biology of the cell, 17(2), 634-644 (2005-11-30)
The anchoring of microtubules (MTs) to subcellular structures is critical for cell shape, polarity, and motility. In mammalian cells, the centrosome is a prominent MT anchoring structure. A number of proteins, including ninein, p150Glued, and EB1, have been implicated in
Aleksandra Mikolajka et al.
Journal of molecular biology, 359(4), 863-875 (2006-05-13)
The fibroblast growth factor receptor 1 (FGFR1) oncogene partner, FOP, is a centrosomal protein that is involved in the anchoring of microtubules (MTS) to subcellular structures. The protein was originally discovered as a fusion partner with FGFR1 in oncoproteins that
C Popovici et al.
Blood, 93(4), 1381-1389 (1999-02-09)
In patients with an atypical stem-cell myeloproliferative disorder with lymphoma (B or T cell), myeloid hyperplasia, and eosinophilia, the chromosome 8p11-12 region is the site of a recurrent breakpoint that can be associated with three different partners, 6q27, 9q32-34, and
G Guasch et al.
Molecular and cellular biology, 21(23), 8129-8142 (2001-11-02)
The FOP-fibroblast growth factor receptor 1 (FGFR1) fusion protein is expressed as a consequence of a t(6;8) (q27;p12) translocation associated with a stem cell myeloproliferative disorder with lymphoma, myeloid hyperplasia and eosinophilia. In the present report, we show that the
Kazuya Ono et al.
PLoS genetics, 10(1), e1004118-e1004118 (2014-01-28)
Inner ear mechanosensory hair cells transduce sound and balance information. Auditory hair cells emerge from a Sox2-positive sensory patch in the inner ear epithelium, which is progressively restricted during development. This restriction depends on the action of signaling molecules. Fibroblast
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