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Principaux documents

AV40528

Sigma-Aldrich

Anti-SFRS10 (AB1) antibody produced in rabbit

IgG fraction of antiserum

Synonyme(s) :

Anti-Splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)

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About This Item

Code UNSPSC :
12352203

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Poids mol.

32 kDa

Espèces réactives

canine, rat, human, rabbit, horse, mouse, pig, bovine

Concentration

0.5 mg - 1 mg/mL

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

NP_004584

Température de stockage

−20°C

Informations sur le gène

human ... SFRS10(6434)

Description générale

Transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (TRA2B, SFRS10) is an alternative splicing regulator that itself exists as alternative splice variants. Alternative mRNA splicing provides transcript diversity. SFRS10 binds SMN1/SMN2 RNA and restores full-length (FL)-SMN2 mRNA levels in vitro. Deficiency of SFRS10 results in early embryonic lethality.

Spécificité

Anti-SFRS10 (AB1) polyclonal antibody reacts with canine, chicken, human, mouse, rat, pig, and bovine transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) proteins.

Immunogène

The immunogen for anti-SFRS10 antibody: synthetic peptide derected towards the N terminal of human SFRS10

Application

Anti-SFRS10 (AB1) polyclonal antibody is used to tag transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) in the regulation of alternative pre-mRNA splicing.

Séquence

Synthetic peptide located within the following region: MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKS

Forme physique

Lyophilized from PBS buffer with 2% sucrose

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
QC9685

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Yupu Diao et al.
Cerebral cortex (New York, N.Y. : 1991), 28(4), 1168-1182 (2017-03-24)
The dorsal Lateral Geniculate Nucleus (dLGN) is the primary image-forming target of the retina and shares a reciprocal connection with primary visual cortex (V1). Previous studies showed that corticothalamic input is essential for the development of thalamocortical projections, but less
Somsakul Pop Wongpalee et al.
eLife, 5 (2016-11-25)
Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear. We found that PTBP1 binding
Thomas C Whisenant et al.
PloS one, 10(12), e0144409-e0144409 (2015-12-08)
Activation of CD4 T cells is a reaction to challenges such as microbial pathogens, cancer and toxins that defines adaptive immune responses. The roles of T cell receptor crosslinking, intracellular signaling, and transcription factor activation are well described, but the
Devi Krishna Priya Karunakaran et al.
Gene expression patterns : GEP, 13(8), 425-436 (2013-08-13)
Processing of mRNAs including, alternative splicing (AS), mRNA transport and translation regulation are crucial to eukaryotic gene expression. For example, >90% of the genes in the human genome are known to undergo alternative splicing thereby expanding the proteome production capacity

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