A7232

AP-18

≥98% (HPLC), solid

• Synonyme(s) : 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
• Formule empirique (notation de Hill) : C₁₁H₁₂ClNO
• Numéro CAS: 55224-94-7
• Poids moléculaire : 209.67
• NACRES: NA.77
• PubChem Substance ID: 329770922
• UNSPSC Code: 12352200
• MDL number: MFCD00102250
• Assay: ≥98% (HPLC)
• Form: solid

Propriétés

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: CC(=C/c1ccc(Cl)cc1)\C(C)=N\O
• InChI: 1S/C11H12ClNO/c1-8(9(2)13-14)7-10-3-5-11(12)6-4-10/h3-7,14H,1-2H3/b8-7+,13-9+
• InChI key: MHTJEUOFLVQMCL-NJHPPEEMSA-N

Description

Application

AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice

Biochem/physiol Actions

AP-18 is a selective TRPA1 channel blocker.

AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mot-clé: Warning
• Codes de danger: H302
• Mentions de précaution: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): dust mask type N95 (US), Eyeshields, Faceshields, Gloves