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A4562

Sigma-Aldrich

5-(N,N-Dimethyl)amiloride hydrochloride

Synonyme(s) :

3-Amino-N-(aminoiminoethyl)-5-(dimethylamino)-6-chloropyrazinecarboxamide hydrochloride, DMA

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About This Item

Formule empirique (notation de Hill):
C8H12ClN7O · HCl
Numéro CAS:
1214-79-5
Poids moléculaire :
294.14
Numéro MDL:
MFCD00069207
Code UNSPSC :
12352200
ID de substance PubChem :
24278216
Nomenclature NACRES :
NA.77

Forme

powder

Niveau de qualité

200

Température de stockage

2-8°C

Chaîne SMILES 

Cl.CN(C)c1nc(N)c(nc1Cl)C(=O)\N=C(\N)N

InChI

1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H

Clé InChI

IIUPTHVVXMBJMQ-UHFFFAOYSA-N

Informations sur le gène

human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548)
mouse ... Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278)
rat ... Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782) , Slc9a2(24783) , Slc9a3(24784)

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Application

5-(N,N-Dimethyl)amiloride hydrochloride is a selective blocker of Na2/H+ antiport. 5-(N,N-Dimethyl)amiloride hydrochloride has been investigated for its ability to reduce inflammatory pain.

Actions biochimiques/physiologiques

Selective blocker of Na+/H+ antiport; IC50 = 6.9 μM.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Yered Pita-Juárez et al.
PLoS computational biology, 14(3), e1006042-e1006042 (2018-03-20)
A goal of genomics is to understand the relationships between biological processes. Pathways contribute to functional interplay within biological processes through complex but poorly understood interactions. However, limited functional references for global pathway relationships exist. Pathways from databases such as
D F Zhao et al.
Nature communications, 8, 14067-14067 (2017-02-22)
The terrestrial vegetation emits large amounts of volatile organic compounds (VOC) into the atmosphere, which on oxidation produce secondary organic aerosol (SOA). By acting as cloud condensation nuclei (CCN), SOA influences cloud formation and climate. In a warming climate, changes
Matija Lovrak et al.
Nature communications, 8, 15317-15317 (2017-06-06)
Self-assembly provides access to a variety of molecular materials, yet spatial control over structure formation remains difficult to achieve. Here we show how reaction-diffusion (RD) can be coupled to a molecular self-assembly process to generate macroscopic free-standing objects with control
Karin Engström et al.
Archives of toxicology, 91(5), 2067-2078 (2016-11-14)
Arsenic, a carcinogen with immunotoxic effects, is a common contaminant of drinking water and certain food worldwide. We hypothesized that chronic arsenic exposure alters gene expression, potentially by altering DNA methylation of genes encoding central components of the immune system.
Peter A Alpert et al.
Scientific reports, 7(1), 12693-12693 (2017-10-06)
Organic interfaces that exist at the sea surface microlayer or as surfactant coatings on cloud droplets are highly concentrated and chemically distinct from the underlying bulk or overlying gas phase. Therefore, they may be potentially unique locations for chemical or
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