52388
α-Homonojirimycin
≥98.0% (TLC)
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Formule empirique (notation de Hill):
C7H15NO5
Numéro CAS:
Poids moléculaire :
193.20
Code UNSPSC :
12352201
ID de substance PubChem :
Nomenclature NACRES :
NA.25
Produits recommandés
Pureté
≥98.0% (TLC)
Chaîne SMILES
OC[C@H]1N[C@H](CO)[C@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6+,7+/m1/s1
Clé InChI
CLVUFWXGNIFGNC-OVHBTUCOSA-N
Application
α-Homonojirimycin (HMJ) is used as an inhibitor of several carbohydrate degrading enzymes including α-glucosidases, glycoprotein processing enzyme glucosidase II and maltase.
Actions biochimiques/physiologiques
α-Homonojirimycin is a potent inhibitor of a range of α-glucosidases, as well as an inhibitor of the glycoprotein processing enzyme glucosidase II.
Conditionnement
Bottomless glass bottle. Contents are inside inserted fused cone.
Autres remarques
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
K Ikeda et al.
Carbohydrate research, 323(1-4), 73-80 (2000-04-27)
2,6-Dideoxy-7-O-(beta-D-glucopyranosyl) 2,6-imino-D-glycero-L-gulo- heptitol (7-O-beta-D-glucopyranosyl-alpha-homonojirimycin, 1) was isolated from the 50% methanol extract of the whole plant of Lobelia sessilifolia (Campanulaceae), which was found to potently inhibit rice alpha-glucosidase. Adenophorae radix, roots of Adenophora spp. (Campanulaceae), yielded new homonojirimycin derivatives, adenophorine
Gabriel M J Lenagh-Snow et al.
Organic letters, 14(8), 2050-2053 (2012-04-05)
Although there are 32 6-azidoheptitols, there are only 16 homonojirimycin (HNJ) stereoisomers. Two epimeric azidoalditols derived from d-mannose allow the synthesis in water of eight stereoisomers of HNJ.
O R Martin et al.
Bioorganic & medicinal chemistry letters, 9(21), 3171-3174 (1999-11-24)
The structure of a homonojirimycin isomer isolated from Aglaonema treublii and originally proposed as alpha-3,4-di-epi-homonojirimycin was revised to alpha-4-epi-homonojirimycin 3 ("alpha-homoallonojirimycin") on the basis of NMR analysis and synthetic studies. Its activity as a glycosidase inhibitor is compared to that
Shankar D Markad et al.
Bioorganic & medicinal chemistry, 14(16), 5535-5539 (2006-05-10)
Conjugate addition of n-butyl amine to d-glucose derived alpha,beta-unsaturated ester 4 afforded beta-amino esters 5a,b that on reduction of ester group, 1,2-acetonide deprotection, and reductive amination led to the formation of corresponding N-butyl 1-deoxy-D-gluco-homonojirimycin 2c and N-butyl 1-deoxy-L-ido-homonojirimycin 2d which
Chinami Kuriyama et al.
Bioorganic & medicinal chemistry, 16(15), 7330-7336 (2008-07-04)
We investigated in vitro inhibition of mammalian carbohydrate-degrading enzymes by six-membered sugar mimics and their evaluation in cell cultures. 1-Deoxynojirimycin (DNJ) showed no significant inhibition toward glycogen phosphorylase (GP) but was a potent inhibitor of another glycogen-degrading enzyme, amylo-1,6-glucosidase (1,6-GL)
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique