Accéder au contenu
Merck
Toutes les photos(1)

Documents

442R-1

Sigma-Aldrich

LEF1 (EP310) Rabbit Monoclonal Primary Antibody

Synonyme(s) :

Lymphoid Enhancing Factor 1

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Code UNSPSC :
12352203

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP310, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (442R-14)
vial of 0.1 mL concentrate Research Use Only (442R-14-RUO)
vial of 0.5 mL concentrate (442R-15)
vial of 1.0 mL concentrate (442R-16)
vial of 1.0 mL concentrate Research Use Only (442R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (442R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (442R-17)
vial of 7.0 mL pre-dilute ready-to-use (442R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (442R-18-RUO)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

Isotype

IgG

Contrôle

small lymphocytic lymphoma, tonsil

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

nuclear

Informations sur le gène

human ... LEF1(51176)

Catégories apparentées

Description générale

Lymphoid Enhancing Factor 1 (LEF1) is a transcription factor that belongs to the TCF/LEF family. LEF1 participates as a regulator in Wnt signaling pathways. LEF1 is an important factor in lymphopoiesis and is expressed normally in T and pro-B cells but not expressed in mature B cells. Strong nuclear expression of LEF1 has been observed in majority of chronic lymphocytic leukemia/small lymphocytic lymphoma cases and LEF1 is not detected in other small B cell lymphomas. Anti-LEF1 may be used as an aid for differentiation of chronic lymphocytic leukemia/small lymphocytic lymphoma from other small B cell lymphomas.

Qualité


IVD
IVD
IVD
RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Not finding the right product?  

Try our Outil de sélection de produits.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Bevan Tandon et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(11), 1433-1443 (2011-06-21)
Lymphoid-enhancer-binding factor 1 (LEF1), coupling with β-catenin, functions as a key nuclear mediator of WNT/β-catenin signaling, which regulates cell proliferation and survival. LEF1 has an important role in lymphopoiesis, and is normally expressed in T and pro-B cells but not
Kata Boras-Granic et al.
Developmental biology, 295(1), 219-231 (2006-05-09)
Inductive reciprocal signaling between mesenchymal and adjacent epithelia gives rise to skin appendages such as hair follicles and mammary glands. Lef1-mediated canonical Wnt signaling is required for morphogenesis of these skin appendages during embryogenesis. In order to define the role
Rajesh Kumar Gandhirajan et al.
Neoplasia (New York, N.Y.), 12(4), 326-335 (2010-04-03)
Lymphoid enhancer factor-1 (lef-1) is overexpressed in B-cell chronic lymphocytic leukemia (CLL) when compared with normal B cells and transcribes several genes implicated in the pathogenesis of CLL. We therefore hypothesize that antagonism of lef-1 might lead to killing of

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique