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Principaux documents

327R-1

Sigma-Aldrich

PSMA (EP192) Rabbit Monoclonal Primary Antibody

Synonyme(s) :

Prostate-specific membrane antigen

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About This Item

Code UNSPSC :
12352203
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP192, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (327R-14)
vial of 0.1 mL concentrate Research Use Only (327R-14-RUO)
vial of 0.5 mL concentrate (327R-15)
vial of 1.0 mL concentrate (327R-16)
vial of 1.0 mL concentrate Research Use Only (327R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (327R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (327R-17)
vial of 7.0 mL pre-dilute ready-to-use (327R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (327R-18-RUO)

Fabricant/nom de marque

Cell Marque®

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:40 (concentrated)

Isotype

IgG

Contrôle

prostate

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic, membranous

Informations sur le gène

human ... FOLH1(2346)

Catégories apparentées

Description générale

Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein with enzymatic activity.[1][2] PSMA is expressed in normal prostate epithelial cells as well as prostate neoplastic cells. It has been demonstrated that PSMA expression is increased in prostate cancer and is correlated with disease progression.[2] Although highly sensitive and specific for prostate, PSMA also labels a subset of non-prostate tissues, including the small intestine and kidney.[2][3] PSMA is useful for identifying metastatic prostate carcinoma[4] and distinguishing prostate carcinoma from urothelial carcinoma.[5]

Qualité


IVD
IVD
IVD
RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

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Autres remarques

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Informations légales

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

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Certificats d'analyse (COA)

Lot/Batch Number
0000402866
0000384292
0000379848
0000329799
0000329800

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Consulter la Bibliothèque de documents

Arundhati Ghosh et al.
Journal of cellular biochemistry, 91(3), 528-539 (2004-02-03)
Prostate specific membrane antigen (PSMA), is a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer as well as neovasculature of most of the solid tumors, but not in the vasculature of the normal tissues. This unique expression
Woo Jin Oh et al.
Journal of pathology and translational medicine, 50(5), 345-354 (2016-08-09)
The pathologic distinction between high-grade prostate adenocarcinoma (PAC) involving the urinary bladder and high-grade urothelial carcinoma (UC) infiltrating the prostate can be difficult. However, making this distinction is clinically important because of the different treatment modalities for these two entities.
Kurt D Bernacki et al.
Diagnostic cytopathology, 42(7), 570-575 (2013-11-26)
The diagnosis of metastatic prostate carcinoma frequently requires the use of immunohistochemical adjuncts. Immunohistochemistry for prostate-specific antigen (PSA) is commonly used for this purpose but can be of limited utility. Recently, prostate-specific membrane antigen (PSMA) has been shown to be
D A Silver et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 3(1), 81-85 (1997-01-01)
Prostate-specific membrane antigen is a type II membrane protein with folate hydrolase activity produced by prostatic epithelium. The expression of this molecule has also been documented in extraprostatic tissues, including small bowel and brain. In the present study, an extensive
Sam S Chang
Reviews in urology, 6 Suppl 10, S13-S18 (2006-09-21)
Efforts to evaluate and discover diagnostic and therapeutic markers for prostate cancer continue. One of these, prostate-specific membrane antigen (PSMA), a transmembrane protein expressed in all types of prostatic tissue, remains a useful diagnostic and possibly therapeutic target. The radio-immunoconjugate

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