258024

(±)-α-Tocophérol

≥95.5%

• Synonyme(s) : DL-tout-rac-α-Tocophérol, Vitamine E
• Formule empirique (notation de Hill): C₂₉H₅₀O₂
• Numéro CAS: 10191-41-0
• Poids moléculaire : 430.71
• Numéro Beilstein : 94012
• Numéro CE : 233-466-0
• Numéro MDL: MFCD00006848
• Code UNSPSC : 12352205
• eCl@ss : 34058016
• ID de substance PubChem : 57648149
• Nomenclature NACRES : NA.28

Propriétés

• Source biologique: synthetic
• Pureté: ≥95.5%
• Forme: liquid
• Technique(s): HPLC: suitable
• Couleur: faint brown to brown; yellow to very dark yellow
• Densité: 0.950 g/mL at 20 °C (lit.)
• Application(s): cell analysis
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1
• InChI: 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
• Clé InChI: GVJHHUAWPYXKBD-UHFFFAOYSA-N

Description

Description générale

α-Tocopherol is the active form of vitamin E. It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses. α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease. It has antiproliferative effects. It inhibits arsenite-induced damage of human fibroblasts.

Application

α-Tocopherol has been used:

• as a standard to determine its concentration by reverse-phase high-performance liquid chromatography
• to study its rescue effects on chlorine dioxide (ClO₂) cytotoxicity
• to assess its protective effects on acetaminophen (APAP)-mediated liver damage

Actions biochimiques/physiologiques

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H317
• Conseils de prudence: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classification des risques: Skin Sens. 1
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Équipement de protection individuelle: Eyeshields, Gloves