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SMB01318

Sigma-Aldrich

3-Hydroxydesloratadine

Synonyme(s) :

3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity

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About This Item

Formule empirique (notation de Hill):
C19H19ClN2O
Numéro CAS:
119410-08-1
Poids moléculaire :
326.82
Numéro MDL:
MFCD00878381
Nomenclature NACRES :
NA.77

Description

Modulation and Signaling

Niveau de qualité

100

Pureté

≥90%

Forme

solid

Technique(s)

HPLC: suitable

Couleur

pale yellow to off-white

Température de stockage

−20°C

InChI

1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2

Clé InChI

NDFMTPISBHBIKE-UHFFFAOYSA-N

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Description générale

3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.

Application

3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research

Actions biochimiques/physiologiques

3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite.

Caractéristiques et avantages

  • High quality compound suitable for multiple research applications
  • Compatible with a wide variety of chromatographic and spectrometry techniques

Autres remarques

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This product is intended for research purposes only, and it is not meant for human consumption.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
MKCP4485

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Consulter la Bibliothèque de documents

Matti K Itkonen et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(4), 377-385 (2019-01-12)
A recent in vitro study suggested that CYP2C8 is essential in the metabolism of desloratadine, an H1 receptor antagonist. If the proposed biotransformation mechanism takes place in vivo in humans, desloratadine could serve as a selective CYP2C8 probe substrate in
Silvi A Chacko et al.
Xenobiotica; the fate of foreign compounds in biological systems, 50(6), 621-629 (2019-10-01)
Accurate prediction of in vivo metabolic pathways in humans can be challenging because in vitro liver matrices may fail to produce certain in vivo metabolites.Rat and human spheroids, generated from cryopreserved hepatocytes in media that contained minimal amount of serum
Faraz Kazmi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(4), 523-533 (2015-01-18)
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that is widely used for the treatment of allergic rhinitis and chronic idiopathic urticaria. For over 20 years, it has remained a mystery as to which

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