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SMB00947

Sigma-Aldrich

N-Desethyl amodiaquine dihydrochloride

≥95%

Synonyme(s) :

Monodesethylamodiaquine dihydrochloride

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About This Item

Formule empirique (notation de Hill):
C18H18ClN3O · 2HCl
Numéro CAS:
79049-30-2
Poids moléculaire :
400.73
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.77

Source biologique

synthetic

Niveau de qualité

200

Pureté

≥95%

Forme

solid

Poids mol.

400.73 g/mol

Technique(s)

HPLC: suitable

Couleur

yellow to dark yellow

Solubilité

DMSO: soluble
methanol: soluble
water: soluble

Température de stockage

2-8°C

Application

Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.
Metabolomics research

Autres remarques

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000377880
0000365297
0000365296
0000365296
0000365297

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Yangshun Tang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 62, 104669-104669 (2019-10-20)
Amodiaquine (ADQ), an antimalarial drug used in endemic areas, has been reported to be associated with liver toxicity; however, the mechanism underlying its hepatoxicity remains unclear. In this study, we examined the cytotoxicity of ADQ and its major metabolite N-desethylamodiaquine
Ahmed A Albassam et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 27(3), 406-412 (2019-04-13)
Pterostilbene is a natural polyphenol compound found in small berries that is related to resveratrol, but has better bioavailability and a longer half-life. The purpose of this study was to assess the potential inhibitory effect of pterostilbene on in vitro
Yingshan Han et al.
Journal of medical virology, 91(7), 1182-1190 (2019-02-26)
Studies aimed at repurposing existing drugs revealed that some antimalarial compounds possess anti-Zika virus (anti-ZIKV) activity. Here, we further tested 14 additional antimalarial drugs and their metabolites or analogs for anti-ZIKV activity using a phenotypic screening approach. We identified four

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