SBR00026

Ligstroside

Nitric oxide inhibitor, ≥95%

• Synonyme(s) : (-)-ligstroside, Ligustroside
• Formule empirique (notation de Hill): C₂₅H₃₂O₁₂
• Numéro CAS: 35897-92-8
• Poids moléculaire : 524.51
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: plant
• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: lyophilized powder
• Poids mol.: 524.51
• Solubilité: DMSO: ≥10 mg/mL (19 mM); methanol: ≥10 mg/mL
• Application(s): metabolomics; vitamins, nutraceuticals, and natural products
• Température de stockage: −20°C
• InChI: 1S/C25H32O12/c1-3-15-16(10-19(28)34-9-8-13-4-6-14(27)7-5-13)17(23(32)33-2)12-35-24(15)37-25-22(31)21(30)20(29)18(11-26)36-25/h3-7,12,16,18,20-22,24-27,29-31H,8-11H2,1-2H3/b15-3+/t16-,18+,20+,21-,22+,24-,25-/m0/s1
• Clé InChI: GMQXOLRKJQWPNB-MVVLSVRYSA-N

Description

Description générale

Ligstroside, also known as ligusroside, is a secoiridoid glycoside, a bioactive natural compound commonly derived from plants like Ligustrum lucidum, Jasminum officinale, and Osmanthus heterophyllus. Existing research suggests that this metabolite functions as an nitric oxide inhibitor and may exhibit diverse biological activities, including anti-neoplastic, antioxidant, antiviral, and anti-inflammatory properties.

Application

Ligstroside is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Actions biochimiques/physiologiques

Ligstroside is a natural product derived from leaves of Olea europaea. Ligstroside displays several potentially beneficial anti-inflammatory properties by exhibiting selective inhibition effect on COX-1 enzyme of arachidonate cascade metabolism. Ligstroside generates a reduction of the PGE₂ (prostaglandin E₂) levels in activated mouse macrophage (IC50 = 48.53 μM) and also reduction of the TXB₂ (thromboxane B₂) levels in human platelets (IC50 = 122.63 μM). Moreover, Ligstroside exhibits inhibition activity of NO production in LPS-activated RAW264.7 macrophages (17.8% at 30 μM and 40.7% at 100 μM) without any cytotoxic effect in these cells.^, Additionally, Ligstroside exhibits in vitro antiviral activity against parainfluenza type 3 virus (IC50 = 15.6 μM).

Caractéristiques et avantages

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

Stockage et stabilité

Hygroscopic; store in dry place with desiccant

Autres remarques

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable