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P7045

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Phenformin hydrochloride

analytical standard

Synonyme(s) :

N-(2-Phenylethyl)imidodicarbonimidic diamide monohydrochloride, Phenethylbiguanide

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About This Item

Formule empirique (notation de Hill):
C10H15N5 · HCl
Numéro CAS:
834-28-6
Poids moléculaire :
241.72
Numéro CE :
212-637-3
Numéro MDL:
MFCD00035039
Code UNSPSC :
41116107
ID de substance PubChem :
329820259
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

Cl.NC(=N)NC(=N)NCCc1ccccc1

InChI

1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H

Clé InChI

YSUCWSWKRIOILX-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Phenformin hydrochloride is a biguanide derivative that shows anti-diabetic activity.

Application

Phenformin hydrochloride has been used as a test compound to study the antineoplastic activity it can exhibit in suppressing the growth of ovarian cancer cells and also human hepatocellular carcinoma cells.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
MKCR3380
MKCQ6399
MKCM5853
MKCJ5461
MKCF2089

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Consulter la Bibliothèque de documents

Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs
Hsu C-C, et al.
Oncology Reports, 34(3), 1620-1628 (2015)
Relevance of the OCT1 transporter to the antineoplastic effect of biguanides
Segal D E, et al.
Biochemical and Biophysical Research Communications, 414(4), 694-699 (2011)
Mozhgan Sedigh-Ardekani et al.
Regulatory toxicology and pharmacology : RTP, 70(2), 514-518 (2014-09-10)
Lactic acidosis occurs in a number of clinical conditions, e.g. in surgeries, orthotopic liver transplant, and anesthetic agent administration, which has deleterious effects on the patient's survival. The most rational therapy for these patients, the sodium bicarbonate administration, cannot prevent
Valentina R Garbarino et al.
Pharmacological research, 140, 21-32 (2018-11-14)
Poorly managed gestational diabetes can lead to severe complications for mother and child including fetal overgrowth, neonatal hypoglycemia and increased autism risk. Use of metformin to control it is relatively new and promising. Yet safety concerns regarding gestational metformin use
Kevin R W Ngoei et al.
Cell chemical biology, 25(6), 728-737 (2018-04-17)
The AMP-activated protein kinase (AMPK) αβγ heterotrimer regulates cellular energy homeostasis with tissue-specific isoform distribution. Small-molecule activation of skeletal muscle α2β2 AMPK complexes may prove a valuable treatment strategy for type 2 diabetes and insulin resistance. Herein, we report the
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