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F1427

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Florfenicol

analytical standard, for drug analysis

Synonyme(s) :

Aquafen, Nuflor, SCH-25298, [R-(R*,S*)]-2,2-Dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide

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About This Item

Formule empirique (notation de Hill):
C12H14Cl2FNO4S
Numéro CAS:
Poids moléculaire :
358.21
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24

Qualité

analytical standard, for drug analysis

Niveau de qualité

Forme

solid

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Format

neat

Chaîne SMILES 

CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl

InChI

1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1

Clé InChI

AYIRNRDRBQJXIF-NXEZZACHSA-N

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Description générale

Florfenicol is a broad-spectrum amphenicol antibiotic used against diseases affecting domestic and wild animals.

Application

The analytical standard can be used as follows:
  • To measure florfenicol and its main metabolite florfenicol amine in tilapia meat by solid phase extraction (SPE) and ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)
  • Multi-residue analysis of three amfenicols in animal feed samples by HPLC-MS/MS method, following European Commission Decision 2002/657/EC(2)Determination of florfenicol in different animal feedstuff samples by thin layer chromatography (TLC) coupled with HPLC-UV detection
  • Residue analysis of florfenicol in broiler meat and liver samples by a reversed phase-HPLC method in combination with UV detection at 223 nm
  • Competitive indirect-chemiluminescent enzyme-linked immunosorbent assay (CL-ELISA) based quantitative analysis of florfenicol and its major metabolite florfenicol amine in chicken muscle samples, validated as per Commission Decision 2002/657/EC

Autres remarques

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogrammes

Health hazardEnvironment

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 1

Organes cibles

Liver,Brain,Testes,Spinal cord,Blood,gallbladder

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


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Certificats d'analyse (COA)

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Les clients ont également consulté

Ye Wang et al.
Biosensors & bioelectronics, 87, 508-513 (2016-09-07)
Herein, a smart single-stranded DNA binding protein (SSB)-assisted fluorescence aptamer switch based on fluorescence resonance energy transfer (FRET) was designed. The FRET switch was synthesized by connecting SSB labeled quantum dots (QDs@SSB) as donor with aptamer (apt) labeled gold nanoparticles
Abdolhossein Jangaran Nejad et al.
Veterinary research forum : an international quarterly journal, 8(4), 327-331 (2018-01-13)
The aim of this study was to evaluate pharmacokinetic profiles of florfenicol after a single dose of intravenous (5.00 mg kg
Peizhen Li et al.
Frontiers in cellular and infection microbiology, 10, 369-369 (2020-09-10)
Bacterial resistance to antibiotics has become an important concern for public health. This study was aimed to investigate the characteristics and the distribution of the florfenicol-related resistance genes in bacteria isolated from four farms. A total of 106 florfenicol-resistant Gram-negative
Joren De Smet et al.
Frontiers in pharmacology, 9, 1265-1265 (2018-11-22)
Florfenicol, which is licensed for veterinary use only, proves to be a potent antimicrobial for treatment of respiratory disease. However, the subsequent exposure of the gut microbiota to florfenicol is not well described. Hence, the effect of various administration protocols
Matthew A Scott et al.
PloS one, 15(1), e0227507-e0227507 (2020-01-14)
Bovine respiratory disease (BRD) is a multifactorial disease complex and the leading infectious disease in post-weaned beef cattle. Clinical manifestations of BRD are recognized in beef calves within a high-risk setting, commonly associated with weaning, shipping, and novel feeding and

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