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74626

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(E)-2-Methylglutaconic acid

≥98.0% (HPLC)

Synonyme(s) :

(2E)-2-Methyl-2-pentenedioic acid, trans-2-Methylglutaconic acid

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About This Item

Formule empirique (notation de Hill):
C6H8O4
Numéro CAS:
53358-21-7
Poids moléculaire :
144.13
Numéro Beilstein :
2096229
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Niveau de qualité

100

Pureté

≥98.0% (HPLC)

Pf

141-147 °C

Application(s)

clinical testing

Format

neat

Température de stockage

2-8°C

InChI

1S/C6H8O4/c1-4(6(9)10)2-3-5(7)8/h2H,3H2,1H3,(H,7,8)(H,9,10)/b4-2+

Clé InChI

JKGHDBJDBRBRNA-DUXPYHPUSA-N

Actions biochimiques/physiologiques

2-Methylglutaconic acid is found in the urine of patients with organic aciduria from 2-methylacetoacetyl-CoA thiolase.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317

Conseils de prudence

P280 - P333 + P313

Classification des risques

Skin Sens. 1

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
BCBQ5328V
BCBQ5328

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Consulter la Bibliothèque de documents

M Duran et al.
Biomedical mass spectrometry, 9(1), 1-5 (1982-01-01)
The identification of (E)-2-methylglutaconic acid, a 'new' metabolite of isoleucine, is described. The substance was detected in urine samples from patients with propionic acidaemia, methylmalonic acidaemia and so-called beta-ketothiolase deficiency; in the majority of cases together with N-tiglylglycine. (E)-2-Methylglutaconic acid
Solution of a classical problem. Tautomerism and isomerism in the α-methylglutaconic acid series
Kagan, J., et al.
The Journal of Organic Chemistry, 40, 3085-3093 (1975)
M Fontaine et al.
Clinica chimica acta; international journal of clinical chemistry, 255(1), 67-83 (1996-11-15)
We report clinical and biological investigations in two patients (twin brothers) with 2-methylacetoacetyl-CoA thiolase deficiency. Main clinical features included important staturo-ponderal delay, frequent infectious rhinopharyngitis episodes and an acute metabolic acidosis at the age of 4 years, this metabolic decompensation
M F Lefevere et al.
Journal of chromatographic science, 27(1), 23-29 (1989-01-01)
High-resolution gas chromatography (HRGC) and gas chromatography/mass spectrometry (GC/MS) are the techniques of choice to determine the retention indices of more than 200 organic acids as their trimethylsilyl (TMS) or oxime-trimethylsilyl derivatives. Several types of apolar and semipolar fused-silica capillary

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