59773
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
analytical standard
Synonyme(s) :
NNAL
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10 MG
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10 MG
458,00 €
About This Item
Formule empirique (notation de Hill) :
C10H15N3O2
Numéro CAS:
Poids moléculaire :
209.25
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24
Produits recommandés
Qualité
analytical standard
Niveau de qualité
Essai
≥92.0% (TLC)
Durée de conservation
limited shelf life, expiry date on the label
Technique(s)
HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable
Application(s)
cleaning products
cosmetics
food and beverages
personal care
Format
neat
Température de stockage
2-8°C
Chaîne SMILES
CN(N=O)CCCC(O)C1=CN=CC=C1
InChI
1S/C10H15N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8,10,14H,3,5,7H2,1H3
Clé InChI
OGRXKBUCZFFSTL-UHFFFAOYSA-N
Catégories apparentées
Description générale
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol is one of the major metabolite of nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, which is a carcinogen responsible in inducing lung cancer in smokers.[1]
Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706031
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Les clients ont également consulté
E M Leslie et al.
The Journal of biological chemistry, 276(30), 27846-27854 (2001-05-29)
Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) play a crucial role in the induction of lung cancer, and NNAL-O-glucuronide formation and elimination are important steps in detoxification of these compounds. In the present study, we investigated the ATP-binding cassette
S S Hecht et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 4(8), 877-884 (1995-12-01)
Epidemiological studies indicate that vegetable consumption protects against lung cancer in humans, but the protective constituents have not been identified. Phenethyl isothiocyanate (PEITC), which is release upon chewing of watercress (nasturtium officinale), is a chemopreventive agent against lung cancer induced
S S Hecht et al.
Carcinogenesis, 18(9), 1851-1854 (1997-11-05)
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is an important metabolite of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Using the chiral derivatizing agent, (R)-(+)-alpha-methylbenzyl isocyanate [(R)-(+)-MBIC], previous work has shown that the enantiomeric ratio of metabolically formed NNAL and its glucuronide derivative may be species dependent.
G B Smith et al.
Carcinogenesis, 20(9), 1809-1818 (1999-09-02)
Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was characterized in human lung cells isolated from peripheral lung specimens obtained from 12 subjects during clinically indicated lobectomy. NNK biotransformation was assessed in preparations of isolated unseparated cells (cell digest), as well
Yuya Kawasaki et al.
Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 42, 26-26 (2020-09-19)
Urinary nicotine and cotinine levels are often measured as biomarkers for tobacco smoke exposure. However, these biomarkers are not appropriate to evaluate the effects of quitting smoking for several days, because of their short half-lives. In this study, we focused
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