Accéder au contenu
Merck
Toutes les photos(1)

Principaux documents

43780

Sigma-Aldrich

Dimethyl 3,3′-dithiopropionimidate dihydrochloride

purum, ≥95.0% (AT)

Synonyme(s) :

DTBP, Dimethyl 3,3′-dithio-bis(propionimidate) dihydrochloride, Wang/Richards’ reagent

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme


About This Item

Formule empirique (notation de Hill) :
C8H16N2O2S2 · 2HCl
Numéro CAS:
Poids moléculaire :
309.28
Numéro MDL:
Code UNSPSC :
12352000
ID de substance PubChem :

Qualité

purum

Essai

≥95.0% (AT)

Température de stockage

2-8°C

Chaîne SMILES 

Cl.Cl.COC(=N)CCSSCCC(=N)OC

InChI

1S/C8H16N2O2S2.2ClH/c1-11-7(9)3-5-13-14-6-4-8(10)12-2;;/h9-10H,3-6H2,1-2H3;2*1H

Clé InChI

CQBCVFHLZAVNPF-UHFFFAOYSA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Application

A homobifunctional, cleavable cross-linking reagent. Typically, reacted with primary amines in the pH range 7.0-10.0 to form amidine bonds.
Reactant for:
  • Synthesis of glutathione-sensitive cross-linked polyethylenimine gene vector
  • Preparation of cyclodextrin-containing polymers designed for gene delivery
  • Crosslinking of chick oviduct progesterone-receptor subunits

Attention

The reagant is readily hydrolyzed at neutral pH. Avoid use of reducing agents during coupling reactions.

Remarque sur l'analyse

product decomposes at 111-115°C, residual melts at 160-164°C

Autres remarques

Note that the amidine linkage preserves original primary amine positive charge. The disulfide linkage is cleavable by mild reduction. Incorporates an eight atom linker.
Cleavable bifunctional reagent used for cross-linking of membrane proteins and hemoglobin; For the preparation of an activated solid support; Cross-linking of a cytochrome oxidase complex

Remplacé(e)(s) par

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Skin Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves


Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

Si vous avez besoin d'assistance, veuillez contacter Service Clients

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Isolation of human erythrocyte membranes and their outer surface proteins by covalent fractionation on solid support.
Y Eshdat et al.
FEBS letters, 101(1), 43-46 (1979-05-01)
K Wang et al.
The Journal of biological chemistry, 250(16), 6622-6626 (1975-08-25)
Dimethyl-3,3'-dithiobispropionimidate penetrates intact human erythrocytes and cross-links many of the membrane proteins to hemoglobin as well as to each other. The cross-linked complexes so produced have been analyzed by both one- and two-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis, making
[Covalently cross-linked, functionally active complex of cholesterol-hydroxylating cytochrome P-450 with adrenodoxin].
S A Usanov et al.
Doklady Akademii nauk SSSR, 280(6), 1487-1491 (1985-01-01)
J Boix et al.
FEBS letters, 272(1-2), 213-216 (1990-10-15)
The organization of the U1snRNP-specific A protein (34 kDa) has been analyzed by 12 and 16 A thiol-reversible chemical cross-linking and Western blotting. A-containing cross-linked complexes had molecular masses of 43, 47, 56, 62, 67, 105 and 125 kDa. None
K Satoh et al.
Biochemistry, 40(2), 314-319 (2001-01-10)
We investigated whether the assembly/disassembly of the 26S proteasome is regulated by phosphorylation/dephosphorylation. The regulatory complex disassembled from the 26S proteasome was capable of phosphorylating the p45/Sug1/Rpt6 subunit, suggesting that the protein kinase is activated upon dissociation of the 26S

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique