08511

Curcumin

analytical standard

• Synonyme(s) : (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3
• Formule linéaire : [HOC₆H₃(OCH₃)CH=CHCO]₂CH₂
• Numéro CAS: 458-37-7
• Poids moléculaire : 368.38
• Numéro C.I. (Colour Index): 75300
• Numéro Beilstein : 2306965
• Numéro CE : 207-280-5
• Numéro MDL: MFCD00008365
• Code UNSPSC : 85151701
• ID de substance PubChem : 329748594
• Numéro E: E100
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: analytical standard
• Niveau de qualité: 100
• Densité de vapeur: 13 (vs air)
• Pureté: ≥98.0% (HPLC)
• Forme: powder
• Durée de conservation: limited shelf life, expiry date on the label
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Application(s): cleaning products; cosmetics; food and beverages; personal care
• Format: neat
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
• InChI: 1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
• Clé InChI: VFLDPWHFBUODDF-FCXRPNKRSA-N

Description

Description générale

Curcumin is an anti-inflammatory agent extracted from the roots of Curcuma longa Linn.

Application

Curcumin may be used as a reference standard for the determination of curcumin in rat plasma by high-performance liquid chromatography method.

Actions biochimiques/physiologiques

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Autres remarques

This compound is commonly found in plants of the genus: curcuma

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable