10602370001

Plasmin, bovine

from bovine plasma

• Synonyme(s) : Plasmin
• Numéro de classification (Commission des enzymes): 3.4.21.7 (BRENDA, IUBMB)
• Code UNSPSC : 12352204

Propriétés

• Source biologique: bovine plasma
• Forme: suspension
• Activité spécifique: ≥2 units/mg protein (At 25 °C with Chromozym PL as the substrate.)
• Poids mol.: M_r ~85 kDa
• Conditionnement: pkg of 1 mL (5 U)
• Fabricant/nom de marque: Roche
• pH optimal: 8.9
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C

Description

Description générale

Plasmin is derived from the proteolytic cleavage of its precursor plasminogen.[1] Human Plasmin is made up of two polypeptide chains. The polypeptide chains are connected via disulfide bridges.[2]

Spécificité

Serine endopeptidase that hydrolyzes peptide and ester bonds at the carboxylic side of Lys or Arg; more selective than trypsin.

Application

Plasmin from bovine has been used as a standard for assessing plasmin biosensors and for proteolytic assays.[3]

Actions biochimiques/physiologiques

Plasmin plays an important role in proteolysis and fibrinolysis.[4][1] It possesses inflammatory activity.[1] Plasmin is also involved in the hydrolysis of peptide bonds following arginine or lysine.[3] It also cleaves hormones like glucagon, thrombopoietin and growth hormones. Plasmin plays a role in cleavage of complement factors like C3 and C5, coagulation factors V and VIII, matrix proteins, growth factors, E-cadherins and metalloproteinase.[1]

Forme physique

Suspension in 3.2 M ammonium sulfate solution

Autres remarques

For life science research only. Not for use in diagnostic procedures.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): does not flash
• Point d'éclair (°C): does not flash