MABS15
Anti-IRS-2 Antibody, clone 9.5.2
clone 9.5.2, from mouse
Synonyme(s) :
insulin receptor substrate 2
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
9.5.2, monoclonal
Espèces réactives
mouse
Réactivité de l'espèce (prédite par homologie)
rat (based on 100% sequence homology)
Technique(s)
western blot: suitable
Isotype
IgG1κ
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... IRS2(8660)
Description générale
Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified that differ as to tissue distribution, subcellular localization, developmental expression, binding to the insulin receptor, and interaction with SH2 domain-containing proteins. In fact, IRS-1 appears to have its major role in skeletal muscle whereas IRS-2 appears to regulate hepatic insulin action as well as pancreatic beta cell development and survival. By contrast, IRS-3 and IRS-4 genes appear to play a redundant role in the IRS signaling system. Defects in muscle IRS-1 expression and function have been reported in insulin-resistant states such as obesity and type 2 diabetes.
Spécificité
This antibody recognizes IRS-2.
Immunogène
Epitope: Unknown
KLH-conjugated linear peptide corresponding to mouse IRS-2.
Application
Anti-IRS-2 Antibody, clone 9.5.2 detects level of IRS-2 & has been published & validated for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
Insulin/Energy Signaling
Insulin/Energy Signaling
Qualité
Evaluated by Western Blot in Insulin treated CHO IR/IRS-2 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IRS-2 on 10 µg of Insulin treated CHO IR/IRS-2 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IRS-2 on 10 µg of Insulin treated CHO IR/IRS-2 cell lysate.
Description de la cible
~ 185 kDa
Liaison
Replaces: 06-506
Forme physique
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Stockage et stabilité
Stable for 1 year at 2-8°C from date of receipt.
Remarque sur l'analyse
Control
Insulin treated CHO IR/IRS-2 cell lysate
Insulin treated CHO IR/IRS-2 cell lysate
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
A Mora et al.
Journal of immunology (Baltimore, Md. : 1950), 166(4), 2218-2227 (2001-02-13)
Proliferative responses of lymphoid cells to IL-2 and IL-4 depend on activation of the cells, but the mechanism(s) by which activation enhances cellular competence to respond to cytokines is not fully understood. The NF-kappaB/Rel family represents one signal transduction pathway
Nipun Saini et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37(10), e23172-e23172 (2023-09-04)
Prenatal alcohol exposure (PAE) impairs fetal growth and neurodevelopment. Although alcohol is well known to alter metabolism, its impact on these processes during pregnancy is largely unexplored. Here, we investigate how alcohol affects maternal-fetal glucose metabolism using our established mouse
Alexandra Kuznetsova et al.
JCI insight, 1(3) (2016-05-07)
The capacity of pancreatic β cells to maintain glucose homeostasis during chronic physiologic and immunologic stress is important for cellular and metabolic homeostasis. Insulin receptor substrate 2 (IRS2) is a regulated adapter protein that links the insulin and IGF1 receptors
Gerta Hoxhaj et al.
PloS one, 8(9), e73327-e73327 (2013-09-17)
Insulin receptor substrate 1 (IRS1) and IRS2 are well-characterized adapter proteins that relay signals from receptor tyrosine kinases to downstream components of signalling pathways. In contrast, the function of IRS4 is not well understood. IRS4 overexpression has been associated with
H Ueno et al.
Molecular biology of the cell, 11(2), 735-746 (2000-02-26)
Insulin receptor substrate (IRS) proteins are docking proteins that couple growth factor receptors to various effector molecules, including phosphoinositide-3 kinase, Grb-2, Syp, and Nck. Here we show that IRS-1 associates with the loop domain of Bcl-2 and synergistically up-regulates antiapoptotic
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