MABD50

Anti-MyT1L Antibody, clone 20B4.1

clone 20B4.1, from mouse

• Synonyme(s) : Myelin transcription factor 1-like protein, MyT1-L, MyT1L
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 20B4.1, monoclonal
• Espèces réactives: human, mouse
• Technique(s): immunohistochemistry: suitable; western blot: suitable
• Isotype: IgG1κ
• Numéro d'accès NCBI: NP_055840
• Numéro d'accès UniProt: Q9UL68
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... MYT1L(23040)

Description

Description générale

Myelin transcription factor 1-like (Myt1L) is a zinc finger protein belonging to the myelin transcription factor 1 family. It influences the expression of genes involved in the proliferation and differentiation of oligodentrocytes in the developing central nervous system. Myt1L may contribute to the silencing of its target genes by recruiting Sin3B that binds to and enhances the activity of HDAC. Several studies have implicated Myt1L in the pathogenesis of complex psychiatric diseases such as schizophrenia, major depressive disorder, and bipolar disorder.

Immunogène

GST-tagged recombinant protein corresponding to human MyT1L.

Application

Detect the MyT1L protein using this Anti-MyT1L, clone 20B4.1 validated for use in WB & IHC.

Immunohistochemistry Analysis: A 1:10-1:50 dilution from a representative lot detected MyT1L in human pons, mouse frontal cortex, and mouse hippocampus tissues.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Qualité

Evaluated by Western Blot in mouse E17 spinal cord tissue lysate.

Western Blot Analysis: A 1:1.000 dilution of this antibody detected MyT1L on 10 µg of mouse E17 spinal cord tissue lysate.

Description de la cible

~170 kDa observed. Uniprot describes three isoforms at 21, 126, and 133 kDa

Forme physique

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Mouse E17 spinal cord tissue lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable