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Key Documents

MAB5504A4

Sigma-Aldrich

Anti-Vesicular Glutamate Transporter 2 Antibody, Alexa Fluor™ 488 | MAB5504A4

clone 8G9.2, from mouse, ALEXA FLUOR™ 488

Synonyme(s) :

Vesicular glutamate transporter 2, VGluT2, Differentiation-associated BNPI, Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, Solute carrier family 17 member 6

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Conjugué

ALEXA FLUOR™ 488

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

8G9.2, monoclonal

Espèces réactives

rat, mouse

Réactivité de l'espèce (prédite par homologie)

human (based on 100% sequence homology)

Technique(s)

immunohistochemistry: suitable

Isotype

IgG1

Numéro d'accès NCBI

NP_445879

Numéro d'accès UniProt

Q9JI12

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SLC17A6(57084)
rat ... Slc17A6(84487)

Description générale

Vesicular Glutamate Transporter 2 (VGLUT2) is a sodium dependent inorganic phosphate cotransporter that is involved in the calcium dependent glutamate release from astrocytes. It is expressed in only a subset of neurons, localized to synaptic vesicles, at synapses exhibiting classical excitatory features. VGLUT2 mRNA is found in brain regions that lack VGLUT1, a related protein also displaying sodium dependent inorganic phosphate cotransporter activity.

Immunogène

Recombinant protein from rat VGLUT2.

Application

Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Qualité

Evaluated by Immunohistochemistry in adult mouse brain tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Vesicular Glutamate Transporter 2 in adult mouse brain tissue.

Description de la cible

The unconjugated parent antibody (Cat. No. MAB5504) has an observed molecular weight at ~56 kDa

Forme physique

Protein A purified
Purified mouse monoclonal IgG1 conjugated to Alexa Fluor™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Stockage et stabilité

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Remarque sur l'analyse

Control
Adult mouse brain tissue

Informations légales

ALEXA FLUOR is a trademark of Life Technologies

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Keerthana Chithanathan et al.
Biology, 11(6) (2022-06-25)
Anxiety is a known comorbidity and risk factor for conversion to neuroinflammation-mediated dementia in patients with Alzheimer's disease (AD). Here, we investigated if anxiety occurred as an early endophenotype of mutant familial AD (5 × FAD) male mice and the
Sami Piirainen et al.
Glia, 69(10), 2459-2473 (2021-06-20)
Microglial activation has been regarded mainly as an exacerbator of stress response, a common symptom in psychiatric disorders. This study aimed to determine whether microglia contribute to adaptive response of the brain and behavior toward stress using a mild and
Keerthana Chithanathan et al.
Frontiers in immunology, 13, 996415-996415 (2022-11-18)
The miR-146 family consists of two microRNAs (miRNAs), miR-146a and miR-146b (miR-146a/b), both of which are known to suppress immune responses in a variety of conditions. Here, we studied how constitutive deficiency of miR-146b (Mir146b-/-) affects lipopolysaccharide (LPS)-induced neuroinflammation in
Ling Yan et al.
Frontiers in cellular neuroscience, 17, 1254923-1254923 (2023-09-29)
Microglia play an important role in the maintenance of brain and behavioral homeostasis. The protective effect of microglial replenishment was reported in neurological diseases, but whether microglial therapy would benefit psychiatric disorders such as schizophrenia has been unclear. As schizophrenia
Friederike Auer et al.
PloS one, 16(3), e0247801-e0247801 (2021-03-03)
Modulation of neuronal excitability is a prominent way of shaping the activity of neuronal networks. Recent studies highlight the role of calcium-activated chloride currents in this context, as they can both increase or decrease excitability. The calcium-activated chloride channel Anoctamin
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