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MAB1974

Sigma-Aldrich

Anti-Integrin β3 Antibody, clone BB10

clone BB10, Chemicon®, from mouse

Synonyme(s) :

CD61

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

BB10, monoclonal

Espèces réactives

human

Fabricant/nom de marque

Chemicon®

Technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

Isotype

IgG1

Adéquation

not suitable for immunohistochemistry (Paraffin)

Numéro d'accès NCBI

NM_000212.2

Numéro d'accès UniProt

P05106

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ITGB3(3690)

Spécificité

Reacts with the beta-3 subunit of the integrin family, including GPIIIa of platelets. Recognized an extracellular epitope of beta-3.

Immunogène

Partially purified platelet glycoprotein IIb/lIIa complex.

Application

Anti-Integrin β3 Antibody, clone BB10 is an antibody against Integrin β3 for use in WB, IC, IH.
Immunoblotting: 1:1000 (Ylanne et al., 1988, 1990). The antibody is most effective when used against non-reduced samples.

immunohistochemistry (indirect immunofluorescence)1:200 - 1:400. (Ylanne et al., 1988).

Does not work on paraffin embedded sections.

Final working dilutions must be determined by end user.

Forme physique

Format: Purified
Purified immunoglobulin. In PBS with 1% BSA and 0.1% sodium azide.

Stockage et stabilité

Maintain between 2 and 8°C up to 12 months.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Réf. du produit
Description
Tarif

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Gwendolyn F Elphick et al.
Blood, 113(17), 4078-4085 (2009-02-27)
Integrin-mediated cell migration is central to many biologic and pathologic processes. During inflammation, tissue injury results from excessive infiltration and sequestration of activated leukocytes. Recombinant human activated protein C (rhAPC) has been shown to protect patients with severe sepsis, although
D Seger et al.
The Journal of biological chemistry, 276(20), 16998-17006 (2001-03-30)
Phosphorylation of vitronectin (Vn) by casein kinase II was previously shown to occur at Thr50 and Thr57 and to augment a major physiological function of vitronectin-cell adhesion and spreading. Here we show that this phosphorylation increases cell adhesion via the
M A Scragg et al.
Infection and immunity, 67(4), 1837-1843 (1999-03-20)
Cell surface integrins mediate interactions between cells and their extracellular matrix and are frequently exploited by a range of bacterial pathogens to facilitate adherence and/or invasion. In this study we examined the effects of Porphyromonas gingivalis proteases on human gingival
Vincent Sarrazy et al.
Cardiovascular research, 102(3), 407-417 (2014-03-19)
Pathological tissue remodelling by myofibroblast contraction is a hallmark of cardiac fibrosis. Myofibroblasts differentiate from cardiac fibroblasts under the action of transforming growth factor-β1 (TGF-β1), which is secreted into the extracellular matrix as a large latent complex. Integrin-mediated traction forces
John C Morrison
Transactions of the American Ophthalmological Society, 104, 453-477 (2007-05-02)
To demonstrate that specific distributions of integrin-based focal mechanoreceptors exist in primate optic nerve heads, suitable for translating stress and strain into the cellular responses of glaucomatous optic neuropathy. Normal human (N = 20) and rhesus monkey (N = 14)
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