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MAB1676

Sigma-Aldrich

Anti-Talin 1 Antibody, NT, a.a. 139-433, clone TA205

clone TA205, Chemicon®, from mouse

Synonyme(s) :

Anti-ILWEQ, Anti-TLN, Anti-talin-1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

TA205, monoclonal

Espèces réactives

rabbit, human

Ne doit pas réagir avec

mouse, rat

Fabricant/nom de marque

Chemicon®

Technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotype

IgG1

Numéro d'accès NCBI

NM_006289.2

Numéro d'accès UniProt

Q9Y490

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TLN1(7094)

Spécificité

Human Talin. This antibody reacts with an N-terminal epitope in talin, between amino acids 139-433. On microinjection into whole cells MAB1676 disrupts actin stress fibers and focal contacts and inhibits cell motility.

Immunogène

Epitope: N-terminus, a.a. 139-433

Application

Anti-Talin 1 Antibody, N-terminus, a.a. 139-433, clone TA205 detects level of Talin & has been published & validated for use in IP, WB, IH.
Immunoblotting, recognizes a band at ~230kDa.

Immunoprecipitation

Immunofluorescence

Optimal working dilutions must be determined by end user.

Forme physique

Format: Purified
Liquid in 0.02 M PB pH 7.6, 0.25 M NaCl containing 0.1% sodium azide.

Stockage et stabilité

Maintain between 2 and 8°C for up to six months.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Karen P Fong et al.
Blood advances, 5(23), 4901-4909 (2021-09-28)
Blood clot contraction is driven by traction forces generated by the platelet cytoskeleton that are transmitted to fibrin fibers via the integrin αIIbβ3. Here we show that clot contraction is impaired by inhibitors of the platelet cytosolic protease calpain. We
Karen P Fong et al.
Cellular microbiology, 8(11), 1753-1767 (2006-07-11)
Actinobacillus actinomycetemcomitans produces a leukotoxin (Ltx) that kills leukocyte function-associated antigen-1 (LFA-1)-bearing cells from man, the Great Apes and Old World monkeys. The unique specificity of Ltx for the beta2 integrin, LFA-1, suggests it is capable of providing insight into
Daniel Friedman et al.
Journal of cell science, 134(7) (2021-03-14)
Natural killer (NK) cells can kill infected or transformed cells via a lytic immune synapse. Diseased cells may exhibit altered mechanical properties but how this impacts NK cell responsiveness is unknown. We report that human NK cells were stimulated more
Maria Salmela et al.
Scientific reports, 7(1), 3414-3414 (2017-06-15)
Conformational activation of integrins is generally required for ligand binding and cellular signalling. However, we have previously reported that the nonactivated conformation of α2β1 integrin can also bind to large ligands, such as human echovirus 1. In this study, we
Li-Ting Su et al.
The Journal of biological chemistry, 281(16), 11260-11270 (2006-01-27)
m-Calpain is a protease implicated in the control of cell adhesion through focal adhesion disassembly. The mechanism by which the enzyme is spatially and temporally controlled is not well understood, particularly because the dependence of calpain on calcium exceeds the
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