Product HX0514 is from bovine testes.
HX0514
Hyaluronidase
Synonyme(s) :
Hyaluronidase
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1 PKG
232,00 €
232,00 €
Date d'expédition estimée le14 avril 2025
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1 PKG
232,00 €
About This Item
232,00 €
Date d'expédition estimée le14 avril 2025
Produits recommandés
Conjugué
conjugate (Glucosaminoglycan)
Niveau de qualité
Forme
powder
Activité spécifique
≥300 units/mg dry wt.
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
Couleur
white
Conditions d'expédition
ambient
Température de stockage
−20°C
Catégories apparentées
Description générale
300 units/mg minimum, 50,000 units/vial. Suitable for biochemistry grade.
Specifications:Activity: 300NF U/mg min
Intended for laboratory and manufacturing use only. Not for drug, food, or household use.
Specifications:Activity: 300NF U/mg min
Intended for laboratory and manufacturing use only. Not for drug, food, or household use.
Application
Hyaluronidase has been used:
- to enzymatically remove extra-cellular matrix (ECM) to assess the lateral diffusion of the synaptic a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR)[1]
- to study the effects of 4-methylumbelliferone (4MU)/ hyaluronidase (HLX)-mediated depletion of the CD44/hyaluronan complex on trastuzumab binding in JIMT1 breast cancer xenografts[2]
- as a component of Hank′s balanced salt solution (HBSS) medium to digest fetal intestine tissue[3]
Actions biochimiques/physiologiques
Hyaluronidase is an endoglycosidase that degrades hyaluronic acid (HA), a component of the extracellular matrix. It is used to enhance drug diffusion and reverse the effects of HA filler injections. Hyaluronidases dissolve the subcutaneous nodules and can correct excessive quantities of injected filler. It eliminates the cumulus-corona-oocyte complex formed during intracytoplasmic sperm injection. Hyaluronidase inhibits tissue damage after the extravasation of several substances. It is used for reducing edema treating vitreous hemorrhage.[4]
Définition de l'unité
One unit is based on the change in absorbency (turbidity) at 540 nm of an internal standard assayed concurrently with each lot. Internal standard replaces USP/NF reference no longer available.
Forme physique
Dialyzed, lyophilized powder, not less than300 units per mg (dry weight).
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Resp. Sens. 1
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Les clients ont également consulté
Maurizio Cavallini et al.
Aesthetic surgery journal, 33(8), 1167-1174 (2013-11-08)
Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive
Alexander D B Ross et al.
STAR protocols, 2(2), 100597-100597 (2021-06-26)
Here, we describe protocols for the preparation and dissociation of human fetal and pediatric intestinal tissue to a high-viability epithelial single-cell suspension. This epithelium-enriched single-cell suspension can then be used to generate single-cell RNA sequencing data as well as to
Sang Hak Lee et al.
eLife, 6 (2017-07-28)
Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and within, post-synaptic densities (PSDs) from rats. Organic fluorescent
Patricia M R Pereira et al.
Molecular pharmaceutics, 17(1), 327-337 (2019-12-06)
Human epidermal growth factor receptor 2 (HER2) is a biomarker in breast cancer, and its overexpression is required to initiate therapies using HER2-targeted antibodies. Although trastuzumab is one of the most effective therapeutic antibodies in HER2-overexpressing breast cancer, a significant
Articles
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
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what is its source?
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What is the appropriate way to reconstitute this? In what medium and at what concentration? Is there an information sheet that provides this information?
1 réponse-
The enzyme can be reconstituted at 1mg/ml in 0.1M Sodium phosphate buffer, pH 5.3 with 0.15M sodium chloride. Stock solutions can be aliquoted and frozen for several months at -20C.
Stock solutions prepared in water (30units/ml) are stable for up to 2 weeks at 4°C and stock solutions prepared in 500 mM acetate buffer, pH 6.0, are stable for up to 1 month at 4°C.
It is recommended to make hyaluronidase solutions fresh. The lyophilized powder is very stable, at least 2 years when stored frozen -20C. This product does not contain a product information sheet.
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