In the Human CVD Panel 3, serum values were found to be significantly lower than plasma values. The median serum value was 5.2 ng/mL, whereas the median plasma value was 2240 ng/mL. For fibrinogen measurement, plasma is the preferred choice due to clot formation. During clotting, protein fibrinogen is converted to fibrin; therefore, HCVD3MAG-67K should be used with plasma for fibrinogen measurement.
HCVD3MAG-67K
MILLIPLEX® Human Cardiovascular Disease (Acute Phase) Magnetic Bead Panel 3 - Cardiovascular Disease Multiplex Assay
The analytes available for this multiplex kit are: Adipsin, AGP, α2-Macroglobulin, CRP, Fetuin A, Fibrinogen, L-Selectin, Serum Amyloid P, Haptoglobin, & Platelet Factor-4.
Synonyme(s) :
human CVD APP immunoassay panel, luminex human cardiovascular disease acute phase proteins multiplex assay, millipore human CVD acute phase proteins multiplex kit
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About This Item
Code UNSPSC :
12161503
eCl@ss :
32161000
Nomenclature NACRES :
NA.84
To order a Milliplex® kit, please search for your analyte of interest.
Produits recommandés
Niveau de qualité
Espèces réactives
human
Fabricant/nom de marque
Milliplex®
assay range
accuracy: 102%
(Haptoglobin)
accuracy: 109%
(AGP)
accuracy: 113%
(Platelet Factor-4)
accuracy: 117%
(Adipsin)
standard curve range: 0.004-15 ng/mL
(L-Selectin & SAP)
standard curve range: 0.012-50 ng/mL
(CRP)
standard curve range: 0.037-150 ng/mL
(PF4)
standard curve range: 0.061-250 ng/mL
(HPTGN)
standard curve range: 0.098-400 ng/mL
(AGP & Adipsin)
standard curve range: 0.244-1,000 ng/mL
(Fetuin A & vWF)
standard curve range: 0.488-2,000 ng/mL
(A2M)
Technique(s)
multiplexing: suitable
Méthode de détection
fluorometric (Luminex xMAP)
Conditions d'expédition
wet ice
Description générale
Cardiovascular disease, particularly atherosclerotic vascular disease, is a leading cause of global mortality, accounting for 30% of all global deaths (WHO, 2010). Inflammatory mechanisms play a vital role in the initiation, maintenance, and progression of vascular disease with a strong correlation between inflammatory markers and prognosis in acute and chronic coronary artery disease. Numerous studies have demonstrated an association of obesity and diabetes with cardiovascular risk factors.
MILLIPLEX® Human Cardiovascular Disease (CVD) Panel 3 (Acute Phase) is a 10-plex kit to be used for the simultaneous quantification of any or all of the following analytes in human serum, plasma or tissue/cell lysate and culture supernatant samples: Adipsin, α-1-Acid-Glycoprotein (AGP), α-2-Macroglobulin (A2M), C Reactive Protein (CRP), Fetuin A, Fibrinogen, L-Selectin, Serum Amyloid P (SAP), Haptoglobin, and Platelet Factor-4 (PF4). (Please note: Fibrinogen is not detectable in serum.) This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Cardiovascular
MILLIPLEX® Human Cardiovascular Disease (CVD) Panel 3 (Acute Phase) is a 10-plex kit to be used for the simultaneous quantification of any or all of the following analytes in human serum, plasma or tissue/cell lysate and culture supernatant samples: Adipsin, α-1-Acid-Glycoprotein (AGP), α-2-Macroglobulin (A2M), C Reactive Protein (CRP), Fetuin A, Fibrinogen, L-Selectin, Serum Amyloid P (SAP), Haptoglobin, and Platelet Factor-4 (PF4). (Please note: Fibrinogen is not detectable in serum.) This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Cardiovascular
Application
- Analytes: α-1 Acid Glycoprotein (AGP), α-2-Macroglobulin (A2M), Adipsin (Factor D), C Reactive Protein (CRP), Fetuin A, Fibrinogen, Haptoglobin, sL-Selectin, Platelet Factor-4 (PF4/CXCL4), Serum Amyloid P (SAP)
- Recommended Sample Type: Human serum, plasma, cell/tissue culture supernatants and lysates
- Recommended Sample Dilution: 25 μL per well of 1:40,000 diluted serum or plasma; tissue/cell culture samples may require dilution in appropriate control medium
- NOTE: Fibrinogen is not detectable in serum
- Assay Run Time: Overnight (16-18 hours) at 2-8°C or 2 hours at room temperature (20-25 °C)
- Research Category: Cardiovascular Disease
- Research Subcategory: Metabolic Disorders
Caractéristiques et avantages
Design your multiplex kit by choosing available analytes within this panel.
Autres remarques
Please contact Technical Service for linearity of dilution.
Sensitivity: See kit protocol for individual analyte sensitivity.
Informations légales
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Mention d'avertissement
Danger
Mentions de danger
Classification des risques
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
Organes cibles
Respiratory system
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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Contenu apparenté
Learn about biomarkers of cardiovascular disease (CVD) and discover how multiplex CVD panels, such as MILLIPLEX® multiplex assays, are being used to increase the efficiency of biomarker discovery for CVD research.
Uncover tips and tricks to multiplexing in this guide from the experts. Learn how you can enhance the power of your research with MILLIPLEX® multiplexing, including industry guidance for immunoassays, multiplexing tips, one-day MILLIPLEX® multiplex assays for limited lab time, and more.
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